Evidence map›Paper›PMID 38139904›Full record

ReviewPolymers2023

Stimuli-Responsive Protein Hydrogels: Their Design, Properties, and Biomedical Applications.

Yuxuan Lu, Yuhe Chen, Yuhan Zhu, Jingyi Zhao, Ketong Ren, Zhao Lu, Jun Li, Ziyang Hao

Abstract readReview
In one paragraph

Review in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Ionic Crosslinking Improves the Stiffness and Toughness of Protein Hydrogels.Polymer science & technology (Washington, D.C.) · 2025
    Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuxuan LuSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0000-0002-2993-8735
Yuhe ChenSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yuhan ZhuSchool of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Jingyi ZhaoSchool of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Ketong RenSchool of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Zhao LuSchool of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Jun LiSchool of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Ziyang HaoSchool of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.

Funding

National Natural Science Foundation of China 32270627
6 · The paper itself

Abstract

Protein-based hydrogels are considered ideal biomaterials due to their high biocompatibility, diverse structure, and their improved bioactivity and biodegradability. However, it remains challenging to mimic the native extracellular matrices that can dynamically respond to environmental stimuli. The combination of stimuli-responsive functionalities with engineered protein hydrogels has facilitated the development of new smart hydrogels with tunable biomechanics and biological properties that are triggered by cyto-compatible stimuli. This review summarizes the recent advancements of responsive hydrogels prepared from engineered proteins and integrated with physical, chemical or biological responsive moieties. We underscore the design principles and fabrication approaches of responsive protein hydrogels, and their biomedical applications in disease treatment, drug delivery, and tissue engineering are briefly discussed. Finally, the current challenges and future perspectives in this field are highlighted.

Indexed as

cross-linking pointmechanical propertiesprotein-based hydrogelsstimuli-responsive

Identifiers

PMID38139904
PMCPMC10747532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.