Evidence map›Paper›PMID 38139394›Full record

ArticleInternational journal of molecular sciences2023

Discovery and Characterization of MaK: A Novel Knottin Antimicrobial Peptide from

Xiaohong Han, Tong Zhou, Xinran Hu, Yukun Zhu, Zengzeng Shi, Shi Chen, Yunfei Liu, Xiaoqian Weng, Feiping Zhang, Songqing Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. The Neurotranscriptome ofInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiaohong HanCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Tong ZhouInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Xinran HuCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Yukun ZhuCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Zengzeng ShiCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Shi ChenCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Yunfei LiuCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Xiaoqian WengCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Feiping ZhangCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Songqing WuCollege of Forestry, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0000-0002-2763-5378
Fujian Agriculture and Forestry University · CNZhejiang University · CN

Funding

Forestry Key Program of Science and Technology in Fujian Province 2021FKJ03Forestry Programs of Science and Technology in Fujian Province Mincaizhi [2020] 601Forestry Science Research Project of Fujian Forestry Department Minlinke [2017] 03National Key R & D Program of China 2021YFD1400900National Natural Science Foundation of China U1905201 and 32171805Natural Science Foundation of Fujian Province, China 2021J01056Science and Technology Program of Fujian Province 2018N5002Scientific Research Foundation of Graduate School of Fujian Agriculture and Forestry University 324-1122yb078Undergraduate Training Program for Innovation and Entrepreneurship of China X202310389146
6 · The paper itself

Abstract

Knottin-type antimicrobial peptides possess exceptional attributes, such as high efficacy, low vulnerability to drug resistance, minimal toxicity, and precise targeting of drug sites. These peptides play a crucial role in the innate immunity of insects, offering protection against bacteria, fungi, and parasites. Knottins have garnered considerable interest as promising contenders for drug development due to their ability to bridge the gap between small molecules and protein-based biopharmaceuticals, effectively addressing the therapeutic limitations of both modalities. This work presents the isolation and identification of a novel antimicrobial peptide derived from

Indexed as

ColeopteraCystine-Knot MiniproteinsNematodaAnimalsAnti-Bacterial AgentsAntimicrobial PeptidesAnti-Bacterial AgentsAntimicrobial PeptidesCystine-Knot Miniproteinsantimicrobial peptidebioactivitybioinformatics analysisBursaphelenchus xylophilusknottin-type peptideMaKMonochamus alternatus

Identifiers

PMID38139394
PMCPMC10743862
OpenAlexW4389915481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.