Evidence map›Paper›PMID 38139378›Full record

ArticleInternational journal of molecular sciences2023

Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4.

Christof Ulrich, Zeynep Canim, Eva Herberger, Matthias Girndt, Roman Fiedler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christof UlrichDepartment of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.ORCID 0000-0002-0639-7876
Zeynep CanimDepartment of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Eva HerbergerDepartment of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Matthias GirndtDepartment of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.ORCID 0000-0003-2823-0847
Roman FiedlerDepartment of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Martin Luther University Halle-Wittenberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypervolemia is associated with inflammation in hemodialysis (HD) patients. How hypervolemia triggers inflammation is not entirely known. We initiated a cross-sectional study enrolling 40 hemodialysis patients who were categorized into normovolemic (N; 23) and hypervolemic (H; 17) groups by bioimpedance measurement. A caspase activity assay in combination with a specific caspase-4 inhibitor was used to detect caspase-4 activity in isolated peripheral blood mononuclear cells (PBMCs). Transcription factors RelA (pS529) and RelB (pS552) were analyzed by phospho-flow cytometry. Serum endotoxins were detected by an amebocyte lysate-based assay, and

Indexed as

CaspasesLeukocytes, MononuclearRenal DialysisTranscription Factor RelBCross-Sectional StudiesEndotoxinsHumansInflammationInterleukin-6Tumor Necrosis Factor-alphaCaspasesEndotoxinsInterleukin-6Transcription Factor RelBTumor Necrosis Factor-alphacaspase-4endotoxinHDhypervolemiainflammationRelARelB

Identifiers

PMID38139378
PMCPMC10743509
OpenAlexW4389885089

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.