Evidence map›Paper›PMID 38139354›Full record

ArticleInternational journal of molecular sciences2023

Eye Washing Downregulated Angiotensin-Converting Enzyme 2 in Conjunctival Tissue Samples from Smokers.

Hiroshi Fujishima, Hiroyuki Yazu, Eisuke Shimizu, Naoko Okada, Kazumi Fukagawa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hiroshi FujishimaDepartment of Ophthalmology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan.ORCID 0000-0002-5926-5826
Hiroyuki YazuDepartment of Ophthalmology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan.ORCID 0000-0002-7371-6558
Eisuke ShimizuKeio Allergy Center, Keio University School of Medicine, Tokyo 160-8582, Japan.ORCID 0000-0002-3422-8578
Naoko OkadaDepartment of Ophthalmology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan.
Kazumi FukagawaKeio Allergy Center, Keio University School of Medicine, Tokyo 160-8582, Japan.
Tsurumi University · JPKeio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to (1) determine whether the expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 is increased in tobacco smokers, which potentially increases their susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and (2) assess whether eye rinsing can reduce susceptibility. This prospective study included 20 eyes of 10 smokers and 18 eyes of nine healthy non-smokers (control) for reverse-transcription polymerase chain reaction. This study also included 28 eyes of 14 smokers and 16 eyes of eight healthy non-smokers (control) for enzyme-linked immunosorbent assay. Tear and impression cytology samples were collected from the right eye of each patient. The left eye was then rinsed for 30 s, and after 5 min, the tear and impression cytology samples were collected in the same manner. The expression of the

Indexed as

Angiotensin-Converting Enzyme 2COVID-19ConjunctivaEyeHumansProspective StudiesRNASARS-CoV-2SmokersAngiotensin-Converting Enzyme 2RNAangiotensin-converting enzyme 2 (ACE2)eye rinsingSARS-CoV-2 infectionsmokingtransmembrane protease serine 2 (TMPRSS2)

Identifiers

PMID38139354
PMCPMC10743887
OpenAlexW4389795000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.