Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper.

Elisa Da Silva, Mark G H Scott, Hervé Enslen, Stefano Marullo

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 35% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Mechanisms of transcriptional regulation of CCR5, which is the co-receptor for R5-tropic HIV and is also involved in other disease processes.Biochemical Society transactions · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elisa Da SilvaCNRS, INSERM, Institut Cochin, Université Paris Cité, F-75014 Paris, France.

Mark G H ScottCNRS, INSERM, Institut Cochin, Université Paris Cité, F-75014 Paris, France.

Hervé EnslenCNRS, INSERM, Institut Cochin, Université Paris Cité, F-75014 Paris, France.ORCID 0000-0001-9741-5293

Stefano MarulloCNRS, INSERM, Institut Cochin, Université Paris Cité, F-75014 Paris, France.ORCID 0000-0001-9604-9973

Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell-surface targeting of neo-synthesized G protein-coupled receptors (GPCRs) involves the recruitment of receptors into COPII vesicles budding at endoplasmic reticulum exit sites (ERESs). This process is regulated for some GPCRs by escort proteins, which facilitate their export, or by gatekeepers that retain the receptors in the ER. PRAF2, an ER-resident four trans- membrane domain protein with cytoplasmic extremities, operates as a gatekeeper for the GB1 protomer of the heterodimeric GABA

Indexed as

Carrier ProteinsMembrane ProteinsReceptors, CCR5Cell MembraneHumansLeucineProtein TransportReceptors, GABA-BReceptors, G-Protein-CoupledCarrier ProteinsCCR5 protein, humanLeucineMembrane ProteinsPRAF2 protein, humanReceptors, CCR5Receptors, GABA-BReceptors, G-Protein-CoupledbiosensorBRETcell traffickingendoplasmic reticulumERESescort proteingatekeeperG protein-coupled receptor

Identifiers

PMID38139265

DOI10.3390/ijms242417438

PMCPMC10744302

OpenAlexW4389685627

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.