Evidence map›Paper›PMID 38139245›Full record

ArticleInternational journal of molecular sciences2023

Effects of Nutraceuticals on Cisplatin-Induced Cytotoxicity in HEI-OC1 Cells.

Lorenzo Guidotti, Elena Tomassi, Silvia Marracci, Michele Lai, Dominga Lapi, Rossana Pesi, Laura Pucci, Ettore Novellino, Elisabetta Albi, Mercedes Garcia-Gil

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Lorenzo GuidottiGeneral Physiology Unit, Department of Biology, University of Pisa, Via San Zeno 31, 56127 Pisa, Italy.ORCID 0009-0000-8335-4821
Elena TomassiInstitute of Agricultural Biology and Biotechnology, Italian National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.ORCID 0009-0006-4151-8000
Silvia MarracciGeneral Physiology Unit, Department of Biology, University of Pisa, Via San Zeno 31, 56127 Pisa, Italy.ORCID 0000-0002-0730-2648
Michele LaiRetrovirus Centre, Department of Translational Medicine and New Technologies in Medicine and Surgery, University of Pisa, Strada Statale del Brennero 2, 56127 Pisa, Italy.ORCID 0000-0001-7597-123X
Dominga LapiGeneral Physiology Unit, Department of Biology, University of Pisa, Via San Zeno 31, 56127 Pisa, Italy.
Rossana PesiBiochemistry Unit, Department of Biology, University of Pisa, Via San Zeno 31, 56127 Pisa, Italy.ORCID 0000-0003-4785-7282
Laura PucciInstitute of Agricultural Biology and Biotechnology, Italian National Research Council, Via Moruzzi 1, 56124 Pisa, Italy.ORCID 0000-0001-7063-6192
Ettore NovellinoFacoltà di Medicina e Chirurgia, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.ORCID 0000-0002-2181-2142
Elisabetta AlbiDepartment of Pharmaceutical Sciences, Interno Orto Botanico, University of Perugia, Via Romana, 06126 Perugia, Italy.
Mercedes Garcia-GilGeneral Physiology Unit, Department of Biology, University of Pisa, Via San Zeno 31, 56127 Pisa, Italy.ORCID 0000-0002-1344-2786
University of Pisa · ITNational Research Council · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Perugia · IT

Funding

University of Pisa ex 60% to M.G.-G.
6 · The paper itself

Abstract

Cisplatin is a chemotherapeutic drug for the treatment of several solid tumors, whose use is limited by its nephrotoxicity, neurotoxicity, ototoxicity, and development of resistance. The toxicity is caused by DNA cross-linking, increase in reactive oxygen species and/or depletion of cell antioxidant defenses. The aim of the work was to study the effect of antioxidant compounds (Lisosan G, Taurisolo

Indexed as

Antineoplastic AgentsCisplatinAntioxidantsApoptosisCaspasesCell SurvivalDietary SupplementsHair Cells, AuditoryReactive Oxygen SpeciesSphingomyelin PhosphodiesteraseSulfidesThiocyanatesAntineoplastic AgentsAntioxidantsCaspasesCisplatinerucinReactive Oxygen SpeciesSphingomyelin PhosphodiesteraseSulfidesThiocyanatesacid sphingomyelinasecisplatinerucinHEI-OC1 cell linehydrogen disulfide donorLisosan GototoxicityTaurisolo®

Identifiers

PMID38139245
PMCPMC10743635
OpenAlexW4389680378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.