Identification of a Gene Encoding a New Fungal Steroid 7-Hydroxylase and Its Functional Characterization in

Vyacheslav Kollerov, Sergey Tarlachkov, Andrei Shutov, Alexey Kazantsev, Marina Donova

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Improved catalytic efficiency of P450 OleP for converting lithocholic acid into murideoxycholic and ursodeoxycholic acids through semi-rational and rational design.Synthetic and systems biotechnology · 2027
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vyacheslav KollerovFederal Research Center «Pushchino Center for Biological Research of the Russian Academy of Sciences», G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Prospekt Nauki, 5, 142290 Pushchino, Russia.ORCID 0000-0002-5623-2930

Sergey TarlachkovFederal Research Center «Pushchino Center for Biological Research of the Russian Academy of Sciences», G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Prospekt Nauki, 5, 142290 Pushchino, Russia.ORCID 0000-0002-0680-5462

Andrei ShutovFederal Research Center «Pushchino Center for Biological Research of the Russian Academy of Sciences», G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Prospekt Nauki, 5, 142290 Pushchino, Russia.ORCID 0000-0002-9501-8072

Alexey KazantsevChemical Department, Moscow State University, GSP-1, Leninskiye Gori, 1, 119991 Moscow, Russia.

Marina DonovaFederal Research Center «Pushchino Center for Biological Research of the Russian Academy of Sciences», G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Prospekt Nauki, 5, 142290 Pushchino, Russia.

G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms · RULomonosov Moscow State University · RU

Funding

Russian Science Foundation 21-64-00024

6 · The paper itself

Abstract

The hydroxylation of steroids in the C7β position is one of the rare reactions that allow the production of value-added precursors in the synthesis of ursodeoxycholic acid and other pharmaceuticals. Recently, we discovered this activity in the ascomycete

Indexed as

Cytochrome P-450 Enzyme SystemSaccharomyces cerevisiaeDehydroepiandrosteroneHydroxylationPichiaSaccharomycetalesSteroidsCytochrome P-450 Enzyme SystemDehydroepiandrosteroneSteroids7β-hydroxylationCurvularia sp.P450-monooxygenaserecombinant Pichia pastorissteroidstranscriptome

Identifiers

PMID38139084

DOI10.3390/ijms242417256

PMCPMC10744122

OpenAlexW4389481194

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.