Evidence map›Paper›PMID 38139034›Full record

ArticleInternational journal of molecular sciences2023

Disrupting Poly(ADP-ribosyl)ating Pathway Creates Premalignant Conditions in Mammalian Liver.

Yaroslava Karpova, David J Orlicky, Edward E Schmidt, Alexei V Tulin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Yaroslava KarpovaDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58202, USA.
David J OrlickyDepartment of Pathology, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-0417-1400
Edward E SchmidtMicrobiology & Cell Biology, Montana State University, Bozeman, MT 59718, USA.
Alexei V TulinDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58202, USA.ORCID 0000-0001-9618-4243
University of North Dakota · USMontana State University · USUniversity of Colorado Denver · US

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
NIGMS NIH HHS P20 GM103442NIGMS NIH HHS P20 GM113123NIGMS NIH HHS U54 GM128729
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a major global health concern, representing one of the leading causes of cancer-related deaths. Despite various treatment options, the prognosis for HCC patients remains poor, emphasizing the need for a deeper understanding of the factors contributing to HCC development. This study investigates the role of poly(ADP-ribosyl)ation in hepatocyte maturation and its impact on hepatobiliary carcinogenesis. A conditional

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsPrecancerous ConditionsAnimalsCarcinogenesisGlycoside HydrolasesHepatocytesHumansMammalsMicePoly Adenosine Diphosphate RiboseGlycoside HydrolasesPoly Adenosine Diphosphate Riboseductal responsehepatocellular carcinomahepatocyte maturationPARGPARP1poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) polymerasetumorigenesis

Identifiers

PMID38139034
PMCPMC10743425
OpenAlexW4389365847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.