Evidence map›Paper›PMID 38139012›Full record

ArticleInternational journal of molecular sciences2023

Untangling Irregular Actin Cytoskeleton Architectures in Tomograms of the Cell with

Salim Sazzed, Peter Scheible, Jing He, Willy Wriggers

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Salim SazzedDepartment of Computer Science, Old Dominion University, Norfolk, VA 23529, USA.ORCID 0000-0002-8552-5337
Peter ScheibleDepartment of Computer Science, Old Dominion University, Norfolk, VA 23529, USA.
Jing HeDepartment of Computer Science, Old Dominion University, Norfolk, VA 23529, USA.ORCID 0000-0002-7249-4746
Willy WriggersDepartment of Mechanical and Aerospace Engineering, Old Dominion University, Norfolk, VA 23529, USA.ORCID 0000-0001-5326-3152
Old Dominion University · US

Funding

Multi-Resolution Docking Methods for Electron MicroscopyR01GM062968 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WRIGGERS, WILLY R · 2001 to 2023
$4.8M
NIGMS NIH HHS R01 GM062968NIH HHS GM062968
6 · The paper itself

Abstract

In this work, we established, validated, and optimized a novel computational framework for tracing arbitrarily oriented actin filaments in cryo-electron tomography maps. Our approach was designed for highly complex intracellular architectures in which a long-range cytoskeleton network extends throughout the cell bodies and protrusions. The irregular organization of the actin network, as well as cryo-electron-tomography-specific noise, missing wedge artifacts, and map dimensions call for a specialized implementation that is both robust and efficient. Our proposed solution,

Indexed as

DictyosteliumActin CytoskeletonActinsAnimalsCytoskeletonElectron Microscope TomographyMiceActinscryo-electron tomographyfilament tracingsegmentation

Identifiers

PMID38139012
PMCPMC10743648
OpenAlexW4389389231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.