Evidence map›Paper›PMID 38139003›Full record

ArticleInternational journal of molecular sciences2023

Reduced Lipopolysaccharide-Binding Protein (LBP) Levels Are Associated with Non-Alcoholic Fatty Liver Disease (NAFLD) and Adipose Inflammation in Human Obesity.

Ilaria Barchetta, Flavia Agata Cimini, Federica Sentinelli, Caterina Chiappetta, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Marco Giorgio Baroni, Maria Gisella Cavallo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  9. Impaired Responses to In Vitro Lipopolysaccharide-Induced Stimulation After Long-Term, Rotating Shift Work.International journal of environmental research and public health · 2025
    Article
  10. Article
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  12. Article
  13. Effect of the total flavonoids ofFrontiers in pharmacology · 2025
    Article
  14. Review
  15. Article
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  17. Microorganisms · 2024
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ilaria BarchettaDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0530-8568
Flavia Agata CiminiDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Federica SentinelliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Caterina ChiappettaDepartment of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, 04100 Latina, Italy.
Claudio Di CristofanoDepartment of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, 04100 Latina, Italy.ORCID 0000-0003-2891-5598
Gianfranco SilecchiaDepartment of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, St Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.
Frida LeonettiDepartment of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, 04100 Latina, Italy.
Marco Giorgio BaroniEndocrinology and Diabetes, Department of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-3224-6078
Maria Gisella CavalloDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6630-8049
Sapienza University of Rome · ITUniversity of L'Aquila · IT

Funding

Sapienza University of Rome Ateneo Grant
6 · The paper itself

Abstract

Lipopolysaccharide (LPS) and its binding protein LBP have emerged as potential contributors to the progression from overweight/obesity to overt metabolic diseases and NAFLD. While LPS is known to activate hepatocyte inflammation, thus contributing toward NAFLD development, the role of LBP is more intricate, and recent data have shown that experimental reduction in hepatic LBP promotes NAFLD progression. In this cross-sectional investigation, we evaluated circulating LBP in relation to obesity, NAFLD, visceral adipose tissue (VAT) inflammation, and type 2 diabetes (T2D). We recruited 186 individuals (M/F: 81/105; age: 47 ± 10.4 years; BMI: 35.5 ± 8.6 kg/m

Indexed as

Diabetes Mellitus, Type 2Non-alcoholic Fatty Liver DiseaseAdultCross-Sectional StudiesHumansInflammationLipopolysaccharide-Binding ProteinLipopolysaccharidesLiverMiddle AgedObesityLipopolysaccharide-Binding ProteinLipopolysaccharidesinsulin resistanceliver fibrosislow-grade inflammationMAFLDMASLDmetabolic syndromeNASHtype 2 diabetesvisceral obesity

Identifiers

PMID38139003
PMCPMC10742626
OpenAlexW4389392619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.