Evidence map›Paper›PMID 38138986›Full record

ArticleInternational journal of molecular sciences2023

Differential H

Amira Zaher, Kranti A Mapuskar, Jann N Sarkaria, Douglas R Spitz, Michael S Petronek, Bryan G Allen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Gallium Uncouples Iron Metabolism to Enhance Glioblastoma Radiosensitivity.International journal of molecular sciences · 2024
    Article
  5. Balanced Duality: HInternational journal of molecular sciences · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amira ZaherDepartment of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-7030-0576
Kranti A MapuskarDepartment of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-7311-7184
Jann N SarkariaDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Douglas R SpitzDepartment of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA.
Michael S PetronekDepartment of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA.
Bryan G AllenDepartment of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Project 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUETTNER, GARRY R · 2018 to 2022
$9.6M
Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
TRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7M
Redox manipulation of iron to improve glioblastoma therapy: A phase 1 trialR21CA270742 · NCI · UNIVERSITY OF IOWA · PI ALLEN, BRYAN, BUATTI, JOHN M · 2023 to 2024
$391k
NCI NIH HHS P01 CA217797NCI NIH HHS P01CA217797NCI NIH HHS P01CA244091NCI NIH HHS P30 CA086862NCI NIH HHS P30CA086862NCI NIH HHS R21 CA270742NCI NIH HHS R21CA270742NCI NIH HHS T32 CA078586NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Glioblastoma (GBM), a highly lethal and aggressive central nervous system malignancy, presents a critical need for targeted therapeutic approaches to improve patient outcomes in conjunction with standard-of-care (SOC) treatment. Molecular subtyping based on genetic profiles and metabolic characteristics has advanced our understanding of GBM to better predict its evolution, mechanisms, and treatment regimens. Pharmacological ascorbate (P-AscH

Indexed as

Antineoplastic AgentsGlioblastomaAntioxidantsAscorbic AcidChemoradiotherapyHumansHydrogen PeroxideAntineoplastic AgentsAntioxidantsAscorbic AcidHydrogen Peroxideantioxidant therapychemoradiationDNA damageglioblastomaglioblastoma subtypeshydrogen peroxidepharmacological ascorbateprooxidant

Identifiers

PMID38138986
PMCPMC10743151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.