Evidence map›Paper›PMID 38138967›Full record

ArticleInternational journal of molecular sciences2023

Dual-Specificity Phosphatase 6 Deficiency Attenuates Arterial-Injury-Induced Intimal Hyperplasia in Mice.

Candra D Hamdin, Meng-Ling Wu, Chen-Mei Chen, Yen-Chun Ho, Wei-Cheng Jiang, Pei-Yu Gung, Hua-Hui Ho, Huai-Chia Chuang, Tse-Hua Tan, Shaw-Fang Yet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Candra D HamdinInstitute of Cellular and System Medicine, National Health Research Institutes, Zhunan 350401, Taiwan.ORCID 0000-0003-2011-2280
Meng-Ling WuCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.ORCID 0000-0002-2916-512X
Chen-Mei ChenInstitute of Cellular and System Medicine, National Health Research Institutes, Zhunan 350401, Taiwan.
Yen-Chun HoCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Wei-Cheng JiangDepartment of Anatomy and Cell Biology, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Pei-Yu GungInstitute of Cellular and System Medicine, National Health Research Institutes, Zhunan 350401, Taiwan.
Hua-Hui HoInstitute of Cellular and System Medicine, National Health Research Institutes, Zhunan 350401, Taiwan.
Huai-Chia ChuangImmunology Research Center, National Health Research Institutes, Zhunan 350401, Taiwan.
Tse-Hua TanImmunology Research Center, National Health Research Institutes, Zhunan 350401, Taiwan.ORCID 0000-0003-4969-3170
Shaw-Fang YetInstitute of Cellular and System Medicine, National Health Research Institutes, Zhunan 350401, Taiwan.ORCID 0000-0001-9097-3962
National Health Research Institutes · TWOklahoma Medical Research Foundation · USNational Yang Ming Chiao Tung University · TW

Funding

National Health Research Institutes CS-112-PP-05National Health Research Institutes and Central Government S & T (Taiwan) 112-0324-01-30-08National Science and Technology Council MOST 109-2320-B-400-026, MOST 111-2326-B-400-007, and NSTC 112-2320-B-400-010)
6 · The paper itself

Abstract

In response to injury, vascular smooth muscle cells (VSMCs) of the arterial wall dedifferentiate into a proliferative and migratory phenotype, leading to intimal hyperplasia. The ERK1/2 pathway participates in cellular proliferation and migration, while dual-specificity phosphatase 6 (DUSP6, also named MKP3) can dephosphorylate activated ERK1/2. We showed that DUSP6 was expressed in low baseline levels in normal arteries; however, arterial injury significantly increased DUSP6 levels in the vessel wall. Compared with wild-type mice,

Indexed as

Dual-Specificity PhosphatasesNeointimaVascular System InjuriesAnimalsCadherinsCell MovementCell ProliferationCells, CulturedDual Specificity Phosphatase 6HyperplasiaMiceMice, Inbred C57BLMyocytes, Smooth MuscleCadherinsDual Specificity Phosphatase 6Dual-Specificity PhosphatasesDusp6 protein, mouseDUSP6migrationproliferationvascular remodelingVSMC

Identifiers

PMID38138967
PMCPMC10742470
OpenAlexW4389348580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.