Evidence map›Paper›PMID 38138934›Full record

ArticleJournal of personalized medicine2023

An Assessment of the Knowledge and Perceptions of Precision Medicine (PM) in the Rwandan Healthcare Setting.

Clarisse Musanabaganwa, Hinda Ruton, Deogratias Ruhangaza, Nicaise Nsabimana, Emmanuel Kayitare, Thierry Zawadi Muvunyi, Muhammed Semakula, Faustin Ntirenganya, Emile Musoni, Jules Ndoli and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Clarisse MusanabaganwaDivision of Research Innovation and Data Science, Rwanda Biomedical Center, Kigali P.O. Box 7162, Rwanda.ORCID 0000-0002-9006-8310
Hinda RutonSchool of Public Health, University of Rwanda, Kigali P.O. Box 3286, Rwanda.
Deogratias RuhangazaButaro District Hospital, Burera P.O. Box 59, Rwanda.
Nicaise NsabimanaButaro District Hospital, Burera P.O. Box 59, Rwanda.
Emmanuel KayitareButaro District Hospital, Burera P.O. Box 59, Rwanda.
Thierry Zawadi MuvunyiKing Faisal Hospital, Kigali P.O. Box 2534, Rwanda.
Muhammed SemakulaDivision of Research Innovation and Data Science, Rwanda Biomedical Center, Kigali P.O. Box 7162, Rwanda.
Faustin NtirenganyaUniversity Teaching Hospital of Kigali, Kigali P.O. Box 655, Rwanda.ORCID 0000-0001-8886-8100
Emile MusoniUniversity Teaching Hospital of Kigali, Kigali P.O. Box 655, Rwanda.
Jules NdoliUniversity Teaching Hospital of Butare, Huye P.O. Box 254, Rwanda.
Elisee HategekimanaUniversity Teaching Hospital of Butare, Huye P.O. Box 254, Rwanda.
Angus NassirKenya Institute of Bioinfomatics, Nairobi P.O. Box 918, Kenya.
Francis MakokhaDirectorate of Research and Development, Mount Kenya University, Thika P.O. Box 342-01000, Kenya.ORCID 0000-0003-3324-4426
Aline UwimanaMalaria and Other Parasitic Diseases Division, Rwanda Biomedical Center, Kigali P.O. Box 7162, Rwanda.
Joel GasanaDivision of Research Innovation and Data Science, Rwanda Biomedical Center, Kigali P.O. Box 7162, Rwanda.
Pierre Celestin MunezeroDepartment of Microbiology and Parasitology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Huye P.O. Box 117, Rwanda.ORCID 0000-0003-2876-9025
Francois UwinkindiDivision of Non-Communicable Diseases, Rwanda Biomedical Center, Kigali P.O. Box 7162, Rwanda.
Claude Mambo MuvunyiDivision of Research Innovation and Data Science, Rwanda Biomedical Center, Kigali P.O. Box 7162, Rwanda.
Laetitia NyirazinyoyeSchool of Public Health, University of Rwanda, Kigali P.O. Box 3286, Rwanda.
Jean Baptiste MazaratiSchool of Medicine, University of Global Health Equity, University of Global Health Equity, Kigali P.O. Box 6955, Rwanda.
Leon MutesaCenter of Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali P.O. Box 4285, Rwanda.ORCID 0000-0002-5308-3706
Rwanda Biomedical Center · RWUniversity of Rwanda · RWUniversity Teaching Hospital of Butare · RWCentre Hospitalier Universitaire de Kigali · RWMount Kenya University · KEUniversity of Global Health Equity · RW

Funding

National Council for Science and Technology (NCST) NCST-ERG-BATCH1/P01/2019
6 · The paper itself

Abstract

introductionPrecision medicine (PM) or personalized medicine is an innovative approach that aims to tailor disease prevention and treatment to consider the differences in people's genes, environments, and lifestyles. Although many efforts have been made to accelerate the universal adoption of PM, several challenges need to be addressed in order to advance PM in Africa. Therefore, our study aimed to establish baseline data on the knowledge and perceptions of the implementation of PM in the Rwandan healthcare setting.

methodA descriptive qualitative study was conducted in five hospitals offering diagnostics and oncology services to cancer patients in Rwanda. To understand the existing policies regarding PM implementation in the country, two additional institutions were surveyed: the Ministry of Health (MOH), which creates and sets policies for the overall vision of the health sector, and the Rwanda Biomedical Center (RBC), which coordinates the implementation of health sector policies in the country. The researchers conducted 32 key informant interviews and assessed the functionality of available PM equipment in the 5 selected health facilities. The data were thematically categorized and analyzed.

resultsThe study revealed that PM is perceived as a complex and expensive program by most health managers and health providers. The most cited challenges to implementing PM included the following: the lack of policies and guidelines; the lack of supportive infrastructures and limited suppliers of required equipment and laboratory consumables; financial constraints; cultural, behavioral, and religious beliefs; and limited trained, motivated, and specialized healthcare providers. Regarding access to health services for cancer treatment, patients with health insurance pay 10% of their medical costs, which is still too expensive for Rwandans.

conclusionThe study participants highlighted the importance of PM to enhance healthcare delivery if the identified barriers are addressed. For instance, Rwandan health sector leadership might consider the creation of specialized oncology centers in all or some referral hospitals with all the necessary genomic equipment and trained staff to serve the needs of the country and implement a PM program.

Indexed as

breast cancercancer healthcare serviceshealthcare providersnational policiesprecision or personalized medicine

Identifiers

PMID38138934
PMCPMC10744509
OpenAlexW4389742532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.