Evidence map›Paper›PMID 38138590›Full record

ArticleMolecules (Basel, Switzerland)2023

Absorption, Distribution, Metabolism, and Excretion of [

Cheng Yang, Mingzhen Xue, Yifei He, Hanwei Yin, Chen Yang, Dafang Zhong, Huihui Zeng, Yuandong Zheng, Xingxing Diao

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cheng YangSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Mingzhen XueJiangsu Key Laboratory for Functional Substances of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Yifei HeShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
Hanwei YinShanghai Yuanxi Pharmaceutical Technology Co., Ltd., Shanghai 201203, China.
Chen YangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
Dafang ZhongShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
Huihui ZengShanghai Yuanxi Pharmaceutical Technology Co., Ltd., Shanghai 201203, China.
Yuandong ZhengShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
Xingxing DiaoSchool of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID 0000-0002-6892-0861
Nanjing University of Chinese Medicine · CNChinese Academy of Sciences · CN

Funding

Key Technologies R&D Program of Guangdong Province 2023B1111030004National Natural Science Foundation of China 82104275National Natural Science Foundation of China 82373938the National Key R&D Program of China 2022YFF1202600
6 · The paper itself

Abstract

BS1801 is a selenium-containing drug candidate with potential for treating liver and lung fibrosis. To fully elucidate the biotransformation of BS1801 in animals and provide sufficient preclinical drug metabolism data for human mass balance study, the metabolism of BS1801 in rats was investigated. We used radiolabeling techniques to investigate the mass balance, tissue distribution, and metabolite identification of BS1801 in Sprague-Dawley/Long-Evans rats after a single oral dose of 100 mg/kg (100 μCi/kg) [

Indexed as

SeleniumAdministration, OralAnimalsBileBiotransformationFecesFemaleHumansLiverMaleRatsRats, Long-EvansRats, Sprague-DawleySelenium[14C]BS1801BS1801 (butaselen)mass balancemetabolismseleniumtissue distribution

Identifiers

PMID38138590
PMCPMC10745422
OpenAlexW4389781392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.