ReviewMolecules (Basel, Switzerland)2023
Epimerisation in Peptide Synthesis.
Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Sustainable Fragment Peptide Synthesis (SFPS): Leveraging Oxyma as a Dual Resin Cleavage-Peptide Coupling Agent.ACS omega · 2026Article
- Iodine-catalyzed green and efficient synthesis of secondary andRSC advances · 2026Article
- Rational Design and Evaluation of Novel TGR5 Agonists for Diabetes.Molecules (Basel, Switzerland) · 2026Article
- Expedient Synthesis ofJournal of the American Chemical Society · 2026Article
- Second-Generation Synthesis and Analytical Application of TBBA for Chiral Analysis of Amino Acids and Oligopeptides byThe Journal of organic chemistry · 2026Article
- Synthesis of Isobenzofuranones and Isoindolinones via Claisen-Schmidt Condensation and Their Antileishmanial Activity.ACS omega · 2026Article
- Exploring and expanding the chemical multiverse of peptides.Chemical science · 2026Review
- Divergent Synthesis of ΔAA-Peptides Using a Bioorthogonal pro-Amino Acid and Aqueous Flavin Photocatalyst: Green Light Enhances Catalyst Performance and Product Selectivity.Angewandte Chemie (International ed. in English) · 2025Article
- Article
- Small Molecule Catalyst for Peptide Synthesis.Journal of the American Chemical Society · 2025Article
- A Supramolecular Extension of Mosher's Method: Absolute Configuration Assignment ofMolecules (Basel, Switzerland) · 2025Article
- Challenges and Achievements of Peptide Synthesis in Aqueous and Micellar Media.Chembiochem : a European journal of chemical biology · 2025Review
- After 75 Years, an Alternative to Edman Degradation: A Mechanistic and Efficiency Study of a Base-Induced Method for N-Terminal Peptide Sequencing.Journal of the American Chemical Society · 2025Article
- A Thiourea Derivative of 2-[(1Molecules (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Epimerisation is basically a chemical conversion that includes the transformation of an epimer into another epimer or its chiral partner. Epimerisation of amino acid is a side reaction that sometimes happens during peptide synthesis. It became the most avoided reaction because the process affects the overall conformation of the molecule, eventually even altering the bioactivity of the peptide. Epimerised products have a high similarity of physical characteristics, thus making it difficult for them to be purified. In regards to amino acids, epimerisation is very important in keeping the chirality of the assembled amino acids unchanged during the peptide synthesis and obtaining the desirable product without any problematic purification. In this review, we report several factors that induce epimerisation during peptide synthesis, including how to characterise and affect the bioactivities. To avoid undesirable epimerisation, we also describe several methods of suppressing the process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.