Evidence map›Paper›PMID 38138471›Full record

ArticleMolecules (Basel, Switzerland)2023

Modified Diatomaceous Earth in Heparin Recovery from Porcine Intestinal Mucosa.

Anushree Das, Devang P Khambhati, Niko D Longoria, Alireza Tabibi, Seyed Mohammad Davachi, Kayli Dimas, Yulianna Laurencin, Lesly Carmona, Pablo Zarate Avalos, Mahmood Karimi Abdolmaleki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Structural Arrangement of Hexadecyltrimethoxysilane on Diatomaceous Earth.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anushree DasDepartment of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA.ORCID 0000-0002-6401-9275
Devang P KhambhatiDepartment of Biology and Chemistry, Texas A&M International University, Laredo, TX 78041, USA.
Niko D LongoriaDepartment of Physical and Environmental Sciences, Texas A&M University Corpus Christi, Corpus Christi, TX 78412, USA.
Alireza TabibiDepartment of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Seyed Mohammad DavachiDepartment of Biology and Chemistry, Texas A&M International University, Laredo, TX 78041, USA.ORCID 0000-0001-7002-3708
Kayli DimasDepartment of Biology and Chemistry, Texas A&M International University, Laredo, TX 78041, USA.
Yulianna LaurencinDepartment of Biology and Chemistry, Texas A&M International University, Laredo, TX 78041, USA.ORCID 0000-0001-5257-6392
Lesly CarmonaDepartment of Biology and Chemistry, Texas A&M International University, Laredo, TX 78041, USA.
Pablo Zarate AvalosDepartment of Biology and Chemistry, Texas A&M International University, Laredo, TX 78041, USA.
Mahmood Karimi AbdolmalekiDepartment of Physical and Environmental Sciences, Texas A&M University Corpus Christi, Corpus Christi, TX 78412, USA.ORCID 0000-0002-0815-187X
Texas A&M International University · USTexas A&M University – Corpus Christi · USIsfahan University of Technology · IRUniversity of Cincinnati · US

Funding

Welch Foundation BS-0051Welch Foundation BT-0041
6 · The paper itself

Abstract

Heparin, a highly sulfated glycosaminoglycan, is a naturally occurring anticoagulant that plays a vital role in various physiological processes. The remarkable structural complexity of heparin, consisting of repeating disaccharide units, makes it a crucial molecule for the development of commercial drugs in the pharmaceutical industry. Over the past few decades, significant progress has been made in the development of cost-effective adsorbents specifically designed for the adsorption of heparin from porcine intestinal mucosa. This advancement has been driven by the need for efficient and scalable methods to extract heparin from natural sources. In this study, we investigated the use of cationic ammonium-functionalized diatomaceous earth, featuring enhanced porosity, larger surface area, and higher thermal stability, to maximize the isolated heparin recovery. Our results showed that the higher cationic density and less bulky quaternary modified diatomaceous earth (QDADE) could adsorb up to 16.3 mg·g

Indexed as

Diatomaceous EarthHeparinAnimalsAnticoagulantsIntestinal MucosaSwineTemperatureAnticoagulantsDiatomaceous EarthHeparinadsorptionamine modified diatomaceous earthcationic diatomaceous earthdiatomaceous earthheparinheparin extractionIRquaternary amine saltviscosity

Identifiers

PMID38138471
PMCPMC10745834
OpenAlexW4389440066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.