Evidence map›Paper›PMID 38138436›Full record

ArticleMolecules (Basel, Switzerland)2023

Identification of Potential Modulators of a Pathogenic G Protein-Gated Inwardly Rectifying K

Eleni Pitsillou, Alexander N O Logothetis, Julia J Liang, Assam El-Osta, Andrew Hung, Asmaa S AbuMaziad, Tom C Karagiannis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 5 countries.

Eleni PitsillouEpigenomic Medicine Laboratory at prospED Polytechnic, Carlton, VIC 3053, Australia.
Alexander N O LogothetisEpigenomic Medicine Laboratory at prospED Polytechnic, Carlton, VIC 3053, Australia.
Julia J LiangEpigenomic Medicine Laboratory at prospED Polytechnic, Carlton, VIC 3053, Australia.ORCID 0000-0002-3031-3169
Assam El-OstaEpigenetics in Human Health and Disease Program, Baker Heart and Diabetes Institute, 75 Commercial Road, Prahran, VIC 3004, Australia.ORCID 0000-0001-7968-7375
Andrew HungSchool of Science, STEM College, RMIT University, Melbourne, VIC 3001, Australia.ORCID 0000-0003-3569-2951
Asmaa S AbuMaziadDepartment of Pediatrics, College of Medicine Tucson, The University of Arizona, Tucson, AZ 85724, USA.
Tom C KaragiannisEpigenomic Medicine Laboratory at prospED Polytechnic, Carlton, VIC 3053, Australia.ORCID 0000-0002-9967-1546
Baker Heart and Diabetes Institute · AURMIT University · AUThe University of Melbourne · AUUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic abnormalities have been associated with primary aldosteronism, a major cause of secondary hypertension. This includes mutations in the

Indexed as

G Protein-Coupled Inwardly-Rectifying Potassium ChannelsHypertensionDrug DiscoveryGTP-Binding ProteinsHumansLigandsMolecular Docking SimulationPeptidesG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGTP-Binding ProteinsKCNJ5 protein, humanLigandsPeptidesGIRK4hypertensioninwardly rectifying K+ channelspathogenic mutationsprimary aldosteronism

Identifiers

PMID38138436
PMCPMC10745636
OpenAlexW4389337325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.