ReviewMicroorganisms2023
Epstein-Barr Virus Encephalitis: A Review of Case Reports from the Last 25 Years.
Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention.MedComm · 2026Review
- Cognition, Cytokines, Blood-Brain Barrier, and Beyond in COVID-19: A Narrative Review.International journal of molecular sciences · 2026Review
- How Epstein Barr virus shapes lupus autoimmunity: mechanistic insights and therapeutic perspectives.Frontiers in immunology · 2026Review
- Adult Epstein-Barr virus encephalitis: a retrospective case report series with metagenomic next-generation sequencing-based diagnosis.Frontiers in neurology · 2026Article
- Article
- Reply to Sheybani et al : Diagnostic criteria for Epstein-Barr virus-associated encephalitis: A comment on Liu et al.Virology journal · 2025Article
- Bilateral acute macular neuroretinopathy after Epstein-Barr virus encephalitis.American journal of ophthalmology case reports · 2025Article
- Case report: anti-argonaute antibodies in Epstein-Barr virus encephalitis.Journal of neurology · 2025Article
- Diagnostic criteria for Epstein-barr virus-associated encephalitis: a comment on Liu et al.Virology journal · 2025Article
- Epstein-Barr Virus Encephalitis Mimicking Herpes Encephalitis On Neuroimaging: A Case Report.Clinical neuroradiology · 2025Article
- Clinical features and risk factors for Epstein-Barr virus-associated encephalitis: a retrospective cohort study.Virology journal · 2025Article
- Epstein-Barr Virus-Associated Encephalitis in an Immunocompetent Adult: A Case Report From Thailand.Case reports in infectious diseases · 2025Article
- Comprehensive performance evaluation of a high-throughput automated system for pathogen nucleic acid detection in clinical settings.Frontiers in microbiology · 2025Article
- Multicountry surveillance study of acute febrile disease of unknown cause in sub-Saharan Africa.BMJ public health · 2025Article
- Article
- Fatal Fulminant Epstein-Barr Virus (EBV) Encephalitis in Immunocompetent 5.5-Year-Old Girl-A Case Report with the Review of Diagnostic and Management Dilemmas.Biomedicines · 2024Article
- "Bilateral Nigral Hyperintensity Sign" in Epstein-Barr Virus Encephalitis.Journal of global infectious diseasesArticle
- Intracranial hypertension due to Epstein-Barr virus encephalitis during the postpartum period.Colombia medica (Cali, Colombia)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although uncommon, Epstein-Barr virus-related neurological disorders represent the seventh most frequent cause of infectious encephalitis in adults. The limited number of publications on EBV encephalitis mainly document isolated clinical cases. This study aimed to summarize published data on EBV encephalitis. A systematic literature search identified 97 EBV encephalitis cases. In the selected cases, EBV-related neurological disorders manifested as lymphocytic pleocytosis in the cerebrospinal fluid (CSF) with moderate hyperproteinorachia. The EBV PCR test was positive in 87% of the CSF samples, with wide-ranging viral loads. When encephalitis occurred in the context of past EBV infections, all of the EBV PCR tests on CSF samples were positive. On the contrary, negative EBV PCR tests on CSF samples occurred only in the context of primary infections. EBV PCR was rarely carried out on blood samples, contributing minimally to the diagnosis. For the treatment of EBV encephalitis, Aciclovir was used alone in 29% of cases, and in association with other drugs in 40% of cases. Ganciclovir (30%), corticoids (52%), and immunoglobulins (15%) were mainly used in association with other drugs. Cerebral imaging was abnormal in 69% of cases, mostly in the cerebellum and basal ganglia. This work highlights that the EBV PCR test on CSF samples is currently the main laboratory diagnostic test to diagnose EBV encephalitis. This diagnostic test is useful; however, it is imperfect. New complementary diagnostic tools, approved treatments, and standardized practices could improve patient management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.