Evidence map›Paper›PMID 38137807›Full record

ReviewJournal of clinical medicine2023

Inflammation in Heart Failure-Future Perspectives.

Alexandru Mircea Arvunescu, Ruxandra Florentina Ionescu, Sanda Maria Cretoiu, Silviu Ionel Dumitrescu, Ondin Zaharia, Ioan Tiberiu Nanea

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexandru Mircea ArvunescuDepartment of Internal Medicine and Cardiology, "Prof. Dr. Th. Burghele" Clinical Hospital, 061344 Bucharest, Romania.
Ruxandra Florentina IonescuDepartment of Cardiology I, Central Military Emergency Hospital "Dr Carol Davila", 030167 Bucharest, Romania.ORCID 0000-0001-9614-7573
Sanda Maria CretoiuDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-2575-4880
Silviu Ionel DumitrescuDepartment of Cardiology I, Central Military Emergency Hospital "Dr Carol Davila", 030167 Bucharest, Romania.
Ondin ZahariaDepartment of Internal Medicine and Cardiology, "Prof. Dr. Th. Burghele" Clinical Hospital, 061344 Bucharest, Romania.
Ioan Tiberiu NaneaDepartment of Internal Medicine and Cardiology, "Prof. Dr. Th. Burghele" Clinical Hospital, 061344 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROTitu Maiorescu University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic heart failure is a terminal point of a vast majority of cardiac or extracardiac causes affecting around 1-2% of the global population and more than 10% of the people above the age of 65. Inflammation is persistently associated with chronic diseases, contributing in many cases to the progression of disease. Even in a low inflammatory state, past studies raised the question of whether inflammation is a constant condition, or if it is, rather, triggered in different amounts, according to the phenotype of heart failure. By evaluating the results of clinical studies which focused on proinflammatory cytokines, this review aims to identify the ones that are independent risk factors for heart failure decompensation or cardiovascular death. This review assessed the current evidence concerning the inflammatory activation cascade, but also future possible targets for inflammatory response modulation, which can further impact the course of heart failure.

Indexed as

CRPfibrinogenheart failureIL-1IL-6inflammationiNOSmyeloperoxidaseproinflammatory cytokinesTNF-α

Identifiers

PMID38137807
PMCPMC10743797
OpenAlexW4389890995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.