Evidence map›Paper›PMID 38137651›Full record

ArticleJournal of clinical medicine2023

Assessing the Assisted Six-Minute Cycling Test as a Measure of Endurance in Non-Ambulatory Patients with Spinal Muscular Atrophy (SMA).

Whitney J Tang, Bo Gu, Samuel Montalvo, Sally Dunaway Young, Dana M Parker, Constance de Monts, Paxton Ataide, Noirin Ni Ghiollagain, Matthew T Wheeler, Carolina Tesi Rocha and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Whitney J TangDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
Bo GuDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
Samuel MontalvoDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Palo Alto, CA 94305, USA.
Sally Dunaway YoungDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.ORCID 0000-0001-9322-0608
Dana M ParkerDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.ORCID 0000-0002-9822-412X
Constance de MontsDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
Paxton AtaideDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
Noirin Ni GhiollagainDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
Matthew T WheelerDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Palo Alto, CA 94305, USA.
Carolina Tesi RochaDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
Jeffrey W ChristleDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Palo Alto, CA 94305, USA.ORCID 0000-0002-3321-6284
Zihuai HeDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
John W DayDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
Tina DuongDepartment of Neurology and Clinical Neurosciences, Stanford University, Palo Alto, CA 94305, USA.
Stanford University · US

Funding

Biogen (United States) VAJPC
6 · The paper itself

Abstract

Assessing endurance in non-ambulatory individuals with Spinal Muscular Atrophy (SMA) has been challenging due to limited evaluation tools. The Assisted 6-Minute Cycling Test (A6MCT) is an upper limb ergometer assessment used in other neurologic disorders to measure endurance. To study the performance of the A6MCT in the non-ambulatory SMA population, prospective data was collected on 38 individuals with SMA (13 sitters; 25 non-sitters), aged 5 to 74 years (mean = 30.3; SD = 14.1). The clinical measures used were A6MCT, Revised Upper Limb Module (RULM), Adapted Test of Neuromuscular Disorders (ATEND), and Egen Klassifikation Scale 2 (EK2). Perceived fatigue was assessed using the Fatigue Severity Scale (FSS), and effort was assessed using the Rate of Perceived Exertion (RPE). Data were analyzed for: (1) Feasibility, (2) Clinical discrimination, and (3) Associations between A6MCT with clinical characteristics and outcomes. Results showed the A6MCT was feasible for 95% of the tested subjects, discriminated between functional groups (

Indexed as

exercisefatigabilityfunctionnusinersenoutcome measurerisdiplamupper extremity

Identifiers

PMID38137651
PMCPMC10743820
OpenAlexW4389478070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.