ReviewJournal of clinical medicine2023
Accuracy of Albumin, Globulin, and Albumin-Globulin Ratio for Diagnosing Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis.
Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Factors associated withJournal of thoracic disease · 2026Article
- Albumin as a predictor of periprosthetic joint infection in patients undergoing total hip arthroplasty and total knee arthroplasty: a retrospective study.Journal of orthopaedic surgery and research · 2026Article
- Aortic Elastic Properties and Albumin-Based Inflammatory Indices in Dyspneic Third-Trimester Pregnant Women: A Prospective Observational Study.Biomedicines · 2026Article
- The diagnostic role of albumin-based ratio markers for periprosthetic joint infection.Frontiers in cellular and infection microbiology · 2026Article
- Clinical application of synovial fluid albumin-to-globulin ratio as a novel biomarker in diagnosing chronic periprosthetic joint infection.Frontiers in cellular and infection microbiology · 2026Article
- A comprehensive analysis of magnetic resonance imaging and laboratory features in pyogenic, tuberculous, brucellar, and fungal spondylitis.Quantitative imaging in medicine and surgery · 2025Article
- Diagnostic work-up in periprosthetic joint infections of the knee: can the albumin-to-globulin ratio be a screening tool?Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Article
- Evaluation of albumin-based inflammatory markers as diagnostic tools in HELLP syndrome.Scientific reports · 2025Article
- Association between serum albumin-to-globulin ratio and subtypes of cerebral atherosclerotic stenosis in acute ischemic stroke.Frontiers in neurology · 2025Article
- Relationship Between Inflammation-Nutrition Composite Indices and Ovarian Endometrioma: A Retrospective Observational Study.Journal of inflammation research · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periprosthetic joint infection (PJI) is one of the most intractable orthopedic diseases, partly because of the difficulty in differentiating septic from aseptic conditions. We aimed to evaluate and consolidate the diagnostic accuracy of the quantitative assessment of serum albumin (Alb), globulin (Glb), and albumin-globulin ratio (AGR), alone or in combination with the inflammatory marker, C-reactive protein (CRP), for PJI. We searched the PubMed, CINAHL, and Cochrane Library databases for studies that quantitatively measured Alb, Glb, or AGR for the diagnosis of PJI up until the 30 April 2023. A total of 2339 patients were included from 10 studies, including 845 patients with a definitive diagnosis of PJI and 1494 with non-PJI. The pooled sensitivity, specificity, and area under the curve (AUC) in the summary receiver-operating characteristic curve were as follows: 0.625, 0.732, and 0.715 for Alb; 0.815, 0.857, and 0.887 for Glb; 0.753, 0.757, and 0.875 for AGR; 0.788, 0.837, and 0.876 for CRP; 0.879, 0.890, and 0.917 for the CRP-Alb ratio; and 0.845, 0.855, and 0.908 for the CRP-AGR ratio. Serum Alb, Glb, and AGR levels are feasible and accurate diagnostic markers for PJI, and the combination of these markers with CRP levels may potentially improve preoperative serum diagnostic accuracy. Future prospective studies are required to verify these findings because of the small numbers of included studies.
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