Evidence map›Paper›PMID 38137486›Full record

ArticleBiomedicines2023

Synthesis, Hydrolytic Stability and In Vivo Biological Study of Bioconjugates of the Tetrapeptides FELL Containing Pyrrole Moiety.

Boryana Borisova, Stanislava Vladimirova, Hristina Nocheva, Marie Laronze-Cochard, Stéphane Gérard, Stoyko Petrin, Dancho Danalev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Boryana BorisovaBiotechnology Department, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd, 1756 Sofia, Bulgaria.
Stanislava VladimirovaOrganic Synthesis Department, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd, 1756 Sofia, Bulgaria.ORCID 0000-0002-2190-9980
Hristina NochevaDepartment of Physiology and Pathophysiology, Faculty of Medicine, Medical University-Sofia, Sv. Georgi Sofiyski Blvd 1, 1431 Sofia, Bulgaria.
Marie Laronze-CochardInstitut de Chimie Moléculaire de Reims (ICMR)-UMR CNRS 7312, Université de Reims Champagne-Ardenne, UFR Pharmacie, 51 rue Cognacq-Jay, 51100 Reims, France.
Stéphane GérardInstitut de Chimie Moléculaire de Reims (ICMR)-UMR CNRS 7312, Université de Reims Champagne-Ardenne, UFR Pharmacie, 51 rue Cognacq-Jay, 51100 Reims, France.ORCID 0000-0002-8307-9986
Stoyko PetrinBiotechnology Department, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd, 1756 Sofia, Bulgaria.ORCID 0000-0001-8347-7039
Dancho DanalevBiotechnology Department, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd, 1756 Sofia, Bulgaria.ORCID 0000-0003-1193-7379
University of Chemical Technology and Metallurgy · BGCentre National de la Recherche Scientifique · FRMedical University of Sofia · BG

Funding

The European Union, NextGenerationEU, through the National Recovery and Resilience Plan of the Republic of Bulgaria project № BG-RRP-2.004-0002, "BiOrgaMCT"
6 · The paper itself

Abstract

backgroundBioconjugates are promising alternatives for the multiple targeting of any disease. Pyrrole heterocycle is well known with many activities and is a building block of a lot of medical drugs. On the other hand, peptides are short molecules with many advantages such as small size, ability to penetrate the cell membrane and bond-specific receptors, vectorizing potential, etc. Thus, hybrid molecules between peptide and pyrrole moiety could be a promising alternative as an anti-pain tool.

methodsNew bioconjugates with a general formula Pyrrole (α-/β-acid)-FELL-OH (NH

resultsThe obtained results reveal that all newly synthesized bioconjugates have analgesic activity according to the used test but free pyrrole acids have the best analgesic activity.

conclusionsAlthough free pyrrole acids showed the best analgesic activity, they are the most unstable for hydrolysis. Combination with peptide structure leads to the hydrolytic stabilization of the bioconjugates, albeit with slightly reduced activity.

Indexed as

analgesic activitybioconguatesFELLhydrolytic stabilitypeptidespyrrole

Identifiers

PMID38137486
PMCPMC10740831
OpenAlexW4389574419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.