Evidence map›Paper›PMID 38137457›Full record

ArticleBiomedicines2023

Blast-Derived Small Extracellular Vesicles in the Plasma of Patients with Acute Myeloid Leukemia Predict Responses to Chemotherapy.

Michael Boyiadzis, Chang-Sook Hong, Saigopalakrishna Yerneni, Annie Im, Brenda Diergaarde, Theresa L Whiteside

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michael BoyiadzisDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
Chang-Sook HongDepartment of Pathology, University of Pittsburgh School of Medicine Pittsburgh, PA 15232, USA.
Saigopalakrishna YerneniDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Annie ImDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
Brenda DiergaardeUPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Theresa L WhitesideDepartment of Pathology, University of Pittsburgh School of Medicine Pittsburgh, PA 15232, USA.ORCID 0000-0001-7316-6181
University of Pittsburgh · USCarnegie Mellon University · US

Funding

Depleting exosomes to improve responses to immune therapy in HNSCCU01DE029759 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITESIDE, THERESA L. · 2020 to 2024
$3.5M
The Adenosinergic Pathway in Tumor-derived ExosomesR01CA256068 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY, WHITESIDE, THERESA L. · 2021 to 2025
$2.5M
Restoring anti-tumor immunity in the microenvironment of head and neck cancerR01CA168628 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITESIDE, THERESA L. · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA168628NCI NIH HHS R01 CA256068NIDCR NIH HHS U01 DE029759NIH HHS R01-256068NIH HHS R01-CA168628NIH HHS U01-DE029759
6 · The paper itself

Abstract

The small extracellular vesicles (sEV) accumulating in acute myeloid leukemia (AML) patients' plasma are mixtures of vesicles produced by leukemic and non-malignant cells. sEV originating from leukemia blasts could serve as potential non-invasive biomarkers of AML response to therapy. To isolate blast-derived sEV from patients' plasma, we developed a bioprinted microarray-based immunoassay using monoclonal antibodies (mAbs) specific for leukemia-associated antigens (LAAs) and mAbs specific for a mix of tetraspanins (CD9, CD63, and CD81). We determined the proportion of LAA

Indexed as

acute myeloid leukemiabiomarkerbioprintingleukemia-associated antigenssmall extracellular vesicles (sEV)therapy responses

Identifiers

PMID38137457
PMCPMC10740822
OpenAlexW4389440469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.