Evidence map›Paper›PMID 38137394›Full record

ArticleBiomedicines2023

Identification and Characterization of Retinitis Pigmentosa in a Novel Mouse Model Caused by PDE6B-T592I.

Chun-Hong Xia, Haiquan Liu, Mei Li, Haiwei Zhang, Xinfang Xing, Xiaohua Gong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chun-Hong XiaHerbert Wertheim School of Optometry and Vision Science Program, University of California, Berkeley, CA 94720, USA.
Haiquan LiuHerbert Wertheim School of Optometry and Vision Science Program, University of California, Berkeley, CA 94720, USA.
Mei LiHerbert Wertheim School of Optometry and Vision Science Program, University of California, Berkeley, CA 94720, USA.
Haiwei ZhangHerbert Wertheim School of Optometry and Vision Science Program, University of California, Berkeley, CA 94720, USA.
Xinfang XingHerbert Wertheim School of Optometry and Vision Science Program, University of California, Berkeley, CA 94720, USA.
Xiaohua GongHerbert Wertheim School of Optometry and Vision Science Program, University of California, Berkeley, CA 94720, USA.
University of California, Berkeley · US

Funding

UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RICHARD H KRAMER · 1985 to 2026
$16.4M
NEI NIH HHS P30 EY003176NIH HHS P30EY003176 (RHK)
6 · The paper itself

Abstract

The cGMP-phosphodiesterase 6 beta subunit (PDE6B) is an essential component in the phototransduction pathway for light responses in photoreceptor cells. PDE6B gene mutations cause the death of rod photoreceptors, named as hereditary retinitis pigmentosa (RP) in humans and retinal degeneration (RD) in rodents. Here, we report a new RD model, identified from a phenotypic screen of N-ethyl-N-nitrosourea (ENU)-induced mutant mice, which displays retinal degeneration caused by a point mutation in the

Indexed as

PDE6Brecombinant adeno-associated virus (rAAV)retinal degeneration (RD)retinal pigmentosa (RP)

Identifiers

PMID38137394
PMCPMC10740990
OpenAlexW4389141854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.