ArticleFoods (Basel, Switzerland)2023
Analysis of the Differentially Expressed Proteins in Donkey Milk in Different Lactation Stages.
Article in Foods (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Donkey Milk Quality and Safety: Challenges of Using the ISO 11816-1 ALP Method for Pasteurization Verification.Foods (Basel, Switzerland) · 2026Article
- The Donkey Genome: From Evolutionary Insights to Sustainable Breeding Strategies.Animals : an open access journal from MDPI · 2025Review
- Overview of Donkey Welfare and Husbandry Practices in Asia.Animals : an open access journal from MDPI · 2025Review
- Advances in Donkey Disease Surveillance and Microbiome Characterization in China.Microorganisms · 2025Review
- Proteomic Profiling of Donkey Milk Exosomes Highlights Bioactive Proteins with Immune-Related Functions.International journal of molecular sciences · 2025Article
- The Milk Compositions and Blood Parameters of Lactating Dezhou Donkeys Changes With Lactation Stages.Veterinary medicine and science · 2025Article
- Methionine Alters the Fecal Microbiota and Enhances the Antioxidant Capacity of Lactating Donkeys.Animals : an open access journal from MDPI · 2025Article
- Gut microbiome regulation in equine animals: current understanding and future perspectives.Frontiers in microbiology · 2025Review
- Comparative Analysis of Angora Rabbit Colostrum and Mature Milk Using Quantitative Proteomics.Biology · 2024Article
- An Overview of Infectious and Non-Infectious Causes of Pregnancy Losses in Equine.Animals : an open access journal from MDPI · 2024Review
- FermentedFrontiers in veterinary science · 2024Article
- A review of genetic resources and trends of omics applications in donkey research: focus on China.Frontiers in veterinary science · 2024Review
- Is there sufficient evidence to support the health benefits of including donkey milk in the diet?Frontiers in nutrition · 2024Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Proteins in donkey milk (DM) have special biological activities. However, the bioactive proteins and their expression regulation in donkey milk are still unclear. Thus, the differentially expressed proteins (DEPs) in DM in different lactation stages were first investigated by data-independent acquisition (DIA) proteomics. A total of 805 proteins were characterized in DM. The composition and content of milk proteins varied with the lactation stage. A total of 445 candidate DEPs related to biological processes and molecular functions were identified between mature milk and colostrum. The 219 down-regulated DEPs were mainly related to complement and coagulation cascades, staphylococcus aureus infection, systemic lupus erythematosus, prion diseases, AGE-RAGE signaling pathways in diabetic complications, and pertussis. The 226 up-regulated DEPs were mainly involved in metabolic pathways related to nutrient (fat, carbohydrate, nucleic acid, and vitamin) metabolism. Some other DEPs in milk from the lactation period of 30 to 180 days also had activities such as promoting cell proliferation, promoting antioxidant, immunoregulation, anti-inflammatory, and antibacterial effects, and enhancing skin moisture. DM can be used as a nutritional substitute for infants, as well as for cosmetic and medical purposes. Our results provide important insights for understanding the bioactive protein differences in DM in different lactation stages.
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