Evidence map›Paper›PMID 38137102›Full record

ArticleBrain sciences2023

Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography.

Alpen Ortug, Briana Valli, José Luis Alatorre Warren, Tadashi Shiohama, Andre van der Kouwe, Emi Takahashi

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Non-transport functions of motor proteins in corticogenesis.Frontiers in cell and developmental biology · 2026
    Review
  2. Imaging of developing human brains with ex vivo PSOCT and dMRI.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Alpen OrtugAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-6813-8351
Briana ValliDepartment of Behavioral Neuroscience, Northeastern University, Boston, MA 02115, USA.
José Luis Alatorre WarrenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA.
Tadashi ShiohamaDepartment of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 260-8677, Japan.ORCID 0000-0003-0076-5882
Andre van der KouweAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA.
Emi TakahashiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA.
Harvard University · USChiba University · JPNortheastern University · US

Funding

Atypical Formation of Fiber Pathways and Cortical Folding in the BrainR01NS109475 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI TAKAHASHI (OKI), EMI · 2019 to 2023
$2.3M
Development of Brain Connectivity in Human Fetus, Newborn, and Toddler AgesR01HD078561 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI TAKAHASHI (OKI), EMI · 2014 to 2018
$1.7M
NICHD NIH HHS R01 HD078561NINDS NIH HHS R01 NS109475
6 · The paper itself

Abstract

Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors. Despite frequent studies about the cortex, comprehensive elucidation of structural abnormalities and their effects on the white matter is limited. The main objective of this study is to analyze abnormal neuronal migration pathways and white matter fiber organization in LIS1-associated LIS using diffusion MRI (dMRI) tractography. For this purpose, slabs of brain specimens with LIS (

Indexed as

DTILIS1lissencephalyMRItractography

Identifiers

PMID38137102
PMCPMC10742067
OpenAlexW4389135403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.