Evidence map›Paper›PMID 38137082›Full record

ArticleBrain sciences2023

The Pathophysiology of Gilles de la Tourette Syndrome: Changes in Saccade Performance by Low-Dose L-Dopa and Dopamine Receptor Blockers.

Yasuo Terao, Yoshiko Nomura, Hideki Fukuda, Okihide Hikosaka, Kazue Kimura, Shun-Ichi Matsuda, Akihiro Yugeta, Francesco Fisicaro, Kyoko Hoshino, Yoshikazu Ugawa

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In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Yasuo TeraoDepartment of Medical Physiology, Kyorin University, Tokyo 181-8611, Japan.
Yoshiko NomuraYoshiko Nomura Neurological Clinic for Children, Tokyo 113-0034, Japan.
Hideki FukudaSegawa Memorial Neurological Clinic for Children, Tokyo 101-0062, Japan.
Okihide HikosakaSection of Neuronal Networks, Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD 20892-2510, USA.
Kazue KimuraSegawa Memorial Neurological Clinic for Children, Tokyo 101-0062, Japan.ORCID 0000-0002-3588-1683
Shun-Ichi MatsudaDepartment of Neurology, University of Tokyo, Tokyo 113-8655, Japan.
Akihiro YugetaDepartment of Neurology, University of Tokyo, Tokyo 113-8655, Japan.
Francesco FisicaroDepartment of Human Neurophysiology, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0002-1579-8807
Kyoko HoshinoSegawa Memorial Neurological Clinic for Children, Tokyo 101-0062, Japan.ORCID 0000-0001-6659-7485
Yoshikazu UgawaDepartment of Human Neurophysiology, Fukushima Medical University, Fukushima 960-1295, Japan.
Segawa Neurological Clinic for Children · JPFukushima Medical University · JPThe University of Tokyo · JPAkebono Clinic · JPKyorin University · JPNational Eye Institute · US

Funding

Communications R&D Promotion Programme from the Ministry of Internal Affairs and Communications, Japan B203060001Ministry of Education, Culture, Sports, Science and Technology of Japan 18H05523Ministry of Education, Culture, Sports, Science and Technology of Japan 19H01091
6 · The paper itself

Abstract

aimTo elucidate the pathophysiology of Gilles de la Tourette syndrome (GTS), which is associated with prior use of dopamine receptor antagonists (blockers) and treatment by L-Dopa, through saccade performance.

methodIn 226 male GTS patients (5-14 years), we followed vocal and motor tics and obsessive-compulsive disorder (OCD) after discontinuing blockers at the first visit starting with low-dose L-Dopa. We recorded visual- (VGS) and memory-guided saccades (MGS) in 110 patients and 26 normal participants.

resultsAt the first visit, prior blocker users exhibited more severe vocal tics and OCD, but not motor tics, which persisted during follow-up. Patients treated with L-Dopa showed greater improvement of motor tics, but not vocal tics and OCD. Patients with and without blocker use showed similarly impaired MGS performance, while patients with blocker use showed more prominently impaired inhibitory control of saccades, associated with vocal tics and OCD. DISCUSSION: Impaired MGS performance suggested a mild hypodopaminergic state causing reduced direct pathway activity in the (oculo-)motor loops of the basal ganglia-thalamocortical circuit. Blocker use may aggravate vocal tics and OCD due to disinhibition within the associative and limbic loops. The findings provide a rationale for discouraging blocker use and using low-dose L-Dopa in GTS.

Indexed as

basal gangliablockerinhibitionobsessive compulsive disorderssaccadetic

Identifiers

PMID38137082
PMCPMC10741739
OpenAlexW4389049777

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.