Evidence map›Paper›PMID 38136993›Full record

ArticleGenes2023

Comparative Genetic Analysis of the Promoters of the ATG16L1 and ATG5 Genes Associated with Sporadic Parkinson's Disease.

Ana Gómez-Martín, José M Fuentes, Joaquín Jordán, María F Galindo, José Luis Fernández-García

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Ana Gómez-MartínNursing Department, Faculty of Nursing and Occupational Therapy, University of Extremadura, Avda de la Universidad s/n, 10003 Cáceres, Spain.
José M FuentesInstituto de Investigación Biosanitaria de Extremadura (INUBE), 10003 Cáceres, Spain.ORCID 0000-0001-6910-2089
Joaquín JordánPharmacology, Medical Sciences Department, Albacete School of Medicine, University of Castilla-La Mancha, 02008 Albacete, Spain.ORCID 0000-0002-6809-3384
María F GalindoPharmaceutical Technologic, Medical Sciences Department, Albacete School of Pharmacy, University of Castilla-La Mancha, 02008 Albacete, Spain.ORCID 0000-0002-7789-7341
José Luis Fernández-GarcíaAnimal Production and Food Science Department, Faculty of Veterinary Sciences, University of Extremadura, Avda. de la Universidad, s/n, 10003 Caceres, Spain.
University of Castilla-La Mancha · ESInstituto de Investigación Biosanitaria de Granada · ESInstituto de Salud Carlos III · ESUniversidad de Extremadura · ES

Funding

Instituto de Salud Carlos III", "CIBERNED" CB06/05/0041
6 · The paper itself

Abstract

Sporadic Parkinson's disease, characterised by a decline in dopamine, usually manifests in people over 65 years of age. Although 10% of cases have a genetic (familial) basis, most PD is sporadic. Genome sequencing studies have associated several genetic variants with sporadic PD. Our aim was to analyse the promoter region of the ATG16L1 and ATG5 genes in sporadic PD patients and ethnically matched controls. Genotypes were obtained by using the Sanger method with primers designed by us. The number of haplotypes was estimated with DnaSP software, phylogeny was reconstructed in Network, and genetic divergence was explored with

Indexed as

Genetic Predisposition to DiseaseParkinson DiseasePromoter Regions, GeneticAutophagy-Related Protein 5Autophagy-Related ProteinsGenotypeHaplotypesHumansATG16L1 protein, humanATG5 protein, humanAutophagy-Related Protein 5Autophagy-Related ProteinsATG16L1autophagygenetic variantsParkinson’s diseasepolymorphismpromotersequencing

Identifiers

PMID38136993
PMCPMC10743014
OpenAlexW4389264265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.