Evidence map›Paper›PMID 38136948›Full record

ArticleGenes2023

Single Nucleotide Polymorphisms Associated with AA-Amyloidosis in Siamese and Oriental Shorthair Cats.

Stella L Esders, Kirsten Hülskötter, Tom Schreiner, Peter Wohlsein, Jessica Schmitz, Jan H Bräsen, Ottmar Distl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Guideline
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stella L EsdersInstitute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.
Kirsten HülskötterDepartment of Pathology, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.ORCID 0000-0003-1577-5856
Tom SchreinerDepartment of Pathology, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.ORCID 0000-0002-0978-2067
Peter WohlseinDepartment of Pathology, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.ORCID 0000-0001-9184-4134
Jessica SchmitzNephropathology Unit, Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-9843-7339
Jan H BräsenNephropathology Unit, Institute of Pathology, Hannover Medical School, 30625 Hannover, Germany.
Ottmar DistlInstitute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.ORCID 0000-0002-3516-836X
University of Veterinary Medicine Hannover, Foundation · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AA-amyloidosis in Siamese and Oriental shorthair cats is a lethal condition in which amyloid deposits accumulate systemically, especially in the liver and the thyroid gland. The age at death of affected cats varies between one and seven years. A previous study indicated a complex mode of inheritance involving a major locus. In the present study, we performed a multi-locus genome-wide association study (GWAS) using five methods (mrMLM, FASTmrMLM, FASTmrEMMA, pLARmEB and ISIS EM-BLASSO) to identify variants associated with AA-amyloidosis in Siamese/Oriental cats. We genotyped 20 affected mixed Siamese/Oriental cats from a cattery and 48 healthy controls from the same breeds using the Illumina Infinium Feline 63 K iSelect DNA array. The multi-locus GWAS revealed eight significantly associated single nucleotide polymorphisms (SNPs) on FCA A1, D1, D2 and D3. The genomic regions harboring these SNPs contain 55 genes, of which 3 are associated with amyloidosis in humans or mice. One of these genes is

Indexed as

AmyloidosisAmyloidosis, FamilialAnimalsCatsChildChild, PreschoolGenomeGenome-Wide Association StudyHumansInfantLiverMicePolymorphism, Single NucleotideSerum Amyloid A ProteinSerum Amyloid A ProteinAA-amyloidosisgenome-wide association studyOriental shorthair catSiamese cat

Identifiers

PMID38136948
PMCPMC10742459
OpenAlexW4389051696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.