ReviewAntibiotics (Basel, Switzerland)2023
Nanoparticles and Their Antibacterial Application in Endodontics.
Review in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Evaluation of the Accuracy of Electronic Apex Locators in Modern Endodontics: An Umbrella Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- From Virtual Modelling to Smarter Endodontic Innovation: In Silico Research for Translational Decision Making.International endodontic journal · 2026Review
- Green-SynthesizedJournal of functional biomaterials · 2026Article
- Applications of Nanomaterials in Restorative Dentistry and Endodontics: A Narrative Review.Materials (Basel, Switzerland) · 2026Review
- Comparative evaluation of chitosan nanoparticles and ethylenediaminetetraacetic acid as intracanal irrigants and their effect on postoperative pain reduction in single-sitting root canal treatment - A randomized controlled trial.Journal of conservative dentistry and endodontics · 2026Article
- The effect of nano chitosan and calcium hydroxide intracanal medications on sealer penetration & bond strength in radicular dentin.BMC oral health · 2026Article
- Mesoporous Bioactive Glass: Preparation, Characterisation, and Emerging Applications in Regenerative Medicine and Dentistry.International dental journal · 2026Review
- Electrically Charged Lipid Nanoparticles as Intracanal Antimicrobial Delivery Systems: A Narrative Review of Preclinical Evidence for Biofilm Control.Dentistry journal · 2026Review
- CombatingJournal of conservative dentistry and endodontics · 2026Article
- Innovative Applications of Nanomaterials in the Diagnosis and Treatment of Ocular Diseases: Targeted Delivery, Intelligent Therapy, Diagnostic Breakthroughs, and Synergistic Strategies with Stem Cells and Biomaterials.International journal of nanomedicine · 2026Review
- Influence of endodontic irrigants on hydraulic cements: solubility, color alteration and surface changes.European oral research · 2026Article
- Nanoparticle-Assisted Endodontic Irrigation: A Systematic Review of Preclinical Studies.Clinical, cosmetic and investigational dentistry · 2026Review
- A Novel Synergistic Carvacrol-Graphene Oxide-Chitosan Nanocomposite for Effective Root Canal Disinfection.International journal of dentistry · 2026Article
- Multifunctional nanoparticles in endodontics: applications, challenges, and future directions.Discover nano · 2025Review
- Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy againstJournal of Taibah University Medical Sciences · 2025Review
- Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy againstJournal of Taibah University Medical Sciences · 2025Article
- Peri-Implantitis Treatment on Microbial Decontamination.Microorganisms · 2025Article
- Microstructural and elemental characterization of novel bioactive glass bioceramic sealer using Fourier transform infrared and X-ray diffraction analysis.Journal of conservative dentistry and endodontics · 2025Article
- Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatment.Pakistan journal of medical sciences · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root canal treatment represents a significant challenge as current cleaning and disinfection methodologies fail to remove persistent bacterial biofilms within the intricate anatomical structures. Recently, the field of nanotechnology has emerged as a promising frontier with numerous biomedical applications. Among the most notable contributions of nanotechnology are nanoparticles, which possess antimicrobial, antifungal, and antiviral properties. Nanoparticles cause the destructuring of bacterial walls, increasing the permeability of the cell membrane, stimulating the generation of reactive oxygen species, and interrupting the replication of deoxyribonucleic acid through the controlled release of ions. Thus, they could revolutionize endodontics, obtaining superior results and guaranteeing a promising short- and long-term prognosis. Therefore, chitosan, silver, graphene, poly(lactic) co-glycolic acid, bioactive glass, mesoporous calcium silicate, hydroxyapatite, zirconia, glucose oxidase magnetic, copper, and zinc oxide nanoparticles in endodontic therapy have been investigated in the present review. The diversified antimicrobial mechanisms of action, the numerous applications, and the high degree of clinical safety could encourage the scientific community to adopt nanoparticles as potential drugs for the treatment of endodontic diseases, overcoming the limitations related to antibiotic resistance and eradication of the biofilm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.