Evidence map›Paper›PMID 38136669›Full record

ArticleBiomolecules2023

Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl

Shroddha Bose, Cecilia de Heus, Mary E Kennedy, Fan Wang, Thomas J Jentsch, Judith Klumperman, Tobias Stauber

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Shroddha BoseInstitute for Molecular Medicine, MSH Medical School Hamburg, 20457 Hamburg, Germany.
Cecilia de HeusCenter for Molecular Medicine/Cell Biology, University Medical Center (UMC), 3584 CX Utrecht, The Netherlands.
Mary E KennedyInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Fan WangInstitute for Molecular Medicine, MSH Medical School Hamburg, 20457 Hamburg, Germany.
Thomas J JentschLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.ORCID 0000-0002-3509-2553
Judith KlumpermanCenter for Molecular Medicine/Cell Biology, University Medical Center (UMC), 3584 CX Utrecht, The Netherlands.
Tobias StauberInstitute for Molecular Medicine, MSH Medical School Hamburg, 20457 Hamburg, Germany.ORCID 0000-0003-0727-6109
MSH Medical School Hamburg – University of Applied Sciences and Medical University · DEUniversity Medical Center Utrecht · NLFreie Universität Berlin · DELeibniz-Forschungsinstitut für Molekulare Pharmakologie · DE

Funding

Deutsche Forschungsgemeinschaft FOR2625
6 · The paper itself

Abstract

ClC-7 is a ubiquitously expressed voltage-gated Cl

Indexed as

OsteopetrosisAnimalsChloride ChannelsGain of Function MutationHumansLysosomesMiceMutationTyrosineChloride ChannelsCLCN7 protein, humanTyrosineautophagychloride/proton exchangeClC-7endo-lysosomeslysosomal storage disorderosmotic pressureOstm1

Identifiers

PMID38136669
PMCPMC10742274
OpenAlexW4389818608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.