ReviewBiomolecules2023
Fungal Laccases: Fundamentals, Engineering and Classification Update.
Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Laccase-Mediated Fabrication of Food Packaging Films: A Critical Review of Functional Performance, Safety, and Industrial Viability.Biomolecules · 2026Review
- Decoding the distribution, structure-function-redox potential relationship and recent advances in fungal laccases: a systematic approach.Bioprocess and biosystems engineering · 2026Review
- Evolutionary diversification of polyketide synthase (PKS) enzymes in Monascus purpureus strains for exploitation as a molecular factory.Archives of microbiology · 2026Article
- Research Progress of Laccase in Edible and Medicinal Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- The multifaceted physiological roles of fungal laccases.Communications biology · 2026Review
- Structural Evolution and Immunomodulatory Versatility of Fungal Immunomodulatory Proteins: Insights into Mechanisms and Bioproduction Strategies.Journal of agricultural and food chemistry · 2026Review
- Mechanistic and Structural Analysis of Aflatoxin B1 Degradation byFoods (Basel, Switzerland) · 2026Article
- A la carte bioprospecting of substrate-selective laccases via high-throughput computational enzyme-substrate interaction profiling.Protein science : a publication of the Protein Society · 2026Article
- Fungal Frontiers in (Bio)sensing.Biosensors · 2026Review
- Directed evolution of LaccID for cell surface proximity labeling and electron microscopy.Nature chemical biology · 2025Article
- Laccase enzyme as a sustainable tool for improving environmental health.Biodegradation · 2025Review
- Biodegradation of synthetic dyes using Aspergillus fumigatus-derived laccase immobilized in alginate matrices.Biodegradation · 2025Article
- Biological Evaluation and Potential Applications of Secondary Metabolites from Fungi Belonging to the Cordycipitaceae Family with a Focus onJournal of fungi (Basel, Switzerland) · 2025Review
- Purification and biochemical characterization of laccase from3 Biotech · 2025Article
- Fungal Laccases with High and Medium Redox Potential: Is the T1 Center Potential a Key Characteristic of Catalytic Efficiency in Heterogeneous and Homogeneous Reactions?International journal of molecular sciences · 2025Article
- Isolation and Characterization of Laccase fromBiology · 2025Article
- Modulation ofInternational journal of molecular sciences · 2025Article
- Exploration and heterologous expression of laccase genes and pesticide degradation ability of laccases from Cerrena unicolor GC.u01.World journal of microbiology & biotechnology · 2025Article
- Two stage enzymatic pretreatment of rice straw for its valorisation using Silicase and Laccase.3 Biotech · 2025Article
- Designing Artificial Laccase Catalysts by Introducing Substrate Oxidation Metals into Oxygen-Reducing Metal-Organic Frameworks: Cu-Doped ZIF-67.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Multicopper oxidases (MCOs) share a common catalytic mechanism of activation by oxygen and cupredoxin-like folding, along with some common structural determinants. Laccases constitute the largest group of MCOs, with fungal laccases having the greatest biotechnological applicability due to their superior ability to oxidize a wide range of aromatic compounds and lignin, which is enhanced in the presence of redox mediators. The adaptation of these versatile enzymes to specific application processes can be achieved through the directed evolution of the recombinant enzymes. On the other hand, their substrate versatility and the low sequence homology among laccases make their exact classification difficult. Many of the ever-increasing amounts of MCO entries from fungal genomes are automatically (and often wrongly) annotated as laccases. In a recent comparative genomic study of 52 basidiomycete fungi, MCO classification was revised based on their phylogeny. The enzymes clustered according to common structural motifs and theoretical activities, revealing three novel groups of laccase-like enzymes. This review provides an overview of the structure, catalytic activity, and oxidative mechanism of fungal laccases and how their biotechnological potential as biocatalysts in industry can be greatly enhanced by protein engineering. Finally, recent information on newly identified MCOs with laccase-like activity is included.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.