Evidence map›Paper›PMID 38136560›Full record

ArticleBiomolecules2023

Functional and Transcriptomic Characterization of Postnatal Maturation of ENS and SIP Syncytium in Mice Colon.

Zhihao Wu, Qianqian Wang, Fan Yang, Jiaxuan Wang, Yuying Zhao, Brian A Perrino, Jie Chen

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Zhihao WuDepartment of General Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong School of Medicine, Shanghai 200127, China.
Qianqian WangDivision of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China.
Fan YangBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-1659-956X
Jiaxuan WangDepartment of General Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong School of Medicine, Shanghai 200127, China.
Yuying ZhaoDepartment of General Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong School of Medicine, Shanghai 200127, China.
Brian A PerrinoDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557, USA.
Jie ChenDepartment of General Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong School of Medicine, Shanghai 200127, China.
Shanghai Children's Medical Center · CNShanghai Jiao Tong University · CNUniversity of Nevada, Reno · US

Funding

Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2022KY390Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2022RC271Science and Technology Commission of Shanghai Municipality 22YF1436800
6 · The paper itself

Abstract

The interplay of the enteric nervous system (ENS) and SIP syncytium (smooth muscle cells-interstitial cells of Cajal-PDGFRα+ cells) plays an important role in the regulation of gastrointestinal (GI) motility. This study aimed to investigate the dynamic regulatory mechanisms of the ENS-SIP system on colon motility during postnatal development. Colonic samples of postnatal 1-week-old (PW1), 3-week-old (PW3), and 5-week-old (PW5) mice were characterized by RNA sequencing, qPCR, Western blotting, isometric force recordings (IFR), and colonic motor complex (CMC) force measurements. Our study showed that the transcriptional expression of

Indexed as

Enteric Nervous SystemReceptor, Platelet-Derived Growth Factor alphaAnimalsColonGene Expression ProfilingGiant CellsMiceReceptor, Platelet-Derived Growth Factor alphacholinergic neuronscolonic motilityenteric nervous systemnitrergic neuronspurinergic receptorsSIP syncytium

Identifiers

PMID38136560
PMCPMC10741935
OpenAlexW4388943044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.