Evidence map›Paper›PMID 38136418›Full record

ArticleCancers2023

Magnetic Resonance Imaging of Macrophage Response to Radiation Therapy.

Harrison Yang, Brock Howerton, Logan Brown, Tadahide Izumi, Dennis Cheek, J Anthony Brandon, Francesc Marti, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Receptor-Mediated SPION Labeling of CD4Nanomaterials (Basel, Switzerland) · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Harrison YangF. Joseph Halcomb III, M.D. Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506, USA.
Brock HowertonShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
Logan BrownF. Joseph Halcomb III, M.D. Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506, USA.
Tadahide IzumiLucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-4855-8436
Dennis CheekDepartment of Radiation Medicine, University of Kentucky, Lexington, KY 40536, USA.
J Anthony BrandonSanders Brown Center on Aging, University of Kentucky, Lexington, KY 40508, USA.
Francesc MartiLucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.
Roberto GedalyLucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.
Reuben AdatorwovorDepartment of Biostatistics, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-0503-3173
Fanny ChapelinShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
University of Kentucky · USUniversity of California San Diego · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
NCATS NIH HHS UL1 TR001998NCI NIH HHS P30 CA177558NIH HHS UL1TR001998
6 · The paper itself

Abstract

backgroundMagnetic resonance imaging (MRI) is a non-invasive imaging modality which, in conjunction with biopsies, provide a qualitative assessment of tumor response to treatment. Intravenous injection of contrast agents such as fluorine (

methodsFemale mice received mammary fat pad injections of murine breast or colon cancer cell lines. The mice then received an intravenous

resultsAcross both cohorts, the RT-treated groups presented significant tumor growth reduction or arrest, contrary to the untreated groups. Similarly, the fluorine signal in treated groups increased significantly as early as four days post therapy. The fluorine signal change correlated to tumor volumes irrespective of time.

conclusionThese results demonstrate the potential of

Indexed as

cancerfluorinemacrophagemagnetic resonance imagingradiation therapytumor microenvironment

Identifiers

PMID38136418
PMCPMC10742077
OpenAlexW4389891635

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.