Evidence map›Paper›PMID 38136361›Full record

ReviewCancers2023

Radiogenomics: Contemporary Applications in the Management of Rectal Cancer.

Niall J O'Sullivan, Hugo C Temperley, Michelle T Horan, Alison Corr, Brian J Mehigan, John O Larkin, Paul H McCormick, Dara O Kavanagh, James F M Meaney, Michael E Kelly

Abstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niall J O'SullivanDepartment of Radiology, St. James's Hospital, D08 NHY1 Dublin, Ireland.ORCID 0000-0002-6241-7819
Hugo C TemperleyDepartment of Surgery, St. James's Hospital, D08 NHY1 Dublin, Ireland.ORCID 0000-0001-9151-3431
Michelle T HoranDepartment of Radiology, St. James's Hospital, D08 NHY1 Dublin, Ireland.ORCID 0000-0002-4813-4847
Alison CorrDepartment of Radiology, St. James's Hospital, D08 NHY1 Dublin, Ireland.
Brian J MehiganSchool of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland.
John O LarkinSchool of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Paul H McCormickSchool of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Dara O KavanaghDepartment of Surgery, Tallaght University Hospital, D24 NR0A Dublin, Ireland.
James F M MeaneyDepartment of Radiology, St. James's Hospital, D08 NHY1 Dublin, Ireland.
Michael E KellySchool of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland.ORCID 0000-0002-0757-6411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiogenomics, a sub-domain of radiomics, refers to the prediction of underlying tumour biology using non-invasive imaging markers. This novel technology intends to reduce the high costs, workload and invasiveness associated with traditional genetic testing via the development of 'imaging biomarkers' that have the potential to serve as an alternative 'liquid-biopsy' in the determination of tumour biological characteristics. Radiogenomics also harnesses the potential to unlock aspects of tumour biology which are not possible to assess by conventional biopsy-based methods, such as full tumour burden, intra-/inter-lesion heterogeneity and the possibility of providing the information of tumour biology longitudinally. Several studies have shown the feasibility of developing a radiogenomic-based signature to predict treatment outcomes and tumour characteristics; however, many lack prospective, external validation. We performed a systematic review of the current literature surrounding the use of radiogenomics in rectal cancer to predict underlying tumour biology.

Indexed as

oncologyradiogenomicsradiomicsrectal cancerrecurrencesurvivaltreatment response

Identifiers

PMID38136361
PMCPMC10741704

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.