Evidence map›Paper›PMID 38136327›Full record

ArticleCancers2023

LincRNA01703 Facilitates CD81

Yun Huang, Shan Guo, Ying Lin, Liyun Huo, Hongmei Yan, Zhanwen Lin, Zishuo Chen, Junchao Cai, Jueheng Wu, Jie Yuan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Rab27: Molecular switch of tumor exosome secretion (Review).International journal of molecular medicine · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. [Mechanisms of Exosomes in Lung Cancer Bone Metastasis and Related Clinical Advances].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025
    Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Yun HuangPrecision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Shan GuoDepartment of Medical Ultrasonics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Ying LinDepartment of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510000, China.
Liyun HuoDepartment of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Hongmei YanSchool of Basic Medical Sciences, Southern Medical University, Guangzhou 510000, China.
Zhanwen LinSchool of Basic Medical Sciences, Southern Medical University, Guangzhou 510000, China.
Zishuo ChenSchool of Basic Medical Sciences, Southern Medical University, Guangzhou 510000, China.
Junchao CaiAdvanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510000, China.
Jueheng WuDepartment of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510000, China.
Jie YuanDepartment of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0002-4147-5585
Hongyu GuanDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Guoyong WuDepartment of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Weibin WuDepartment of Cardiothoracic Surgery, The Third Affiliated Hospitalof Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0002-2272-8735
Tianyu TaoPrecision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.ORCID 0000-0003-1973-5552
Sun Yat-sen University · CNSouthern Medical University · CN

Funding

the Funding on Guangdong Marine Economy Development Special Project No. GDNRC [2022]35the Natural Science Foundation of China 81820108025the Natural Science Foundation of China 82030088the Natural Science Foundation of China 82073050the Natural Science Foundation of Guangdong Province 2022A1515111072the Natural Science Foundation of Guangdong Province 2023A1515010289
6 · The paper itself

Abstract

Metastasis, a major cause of cancer-related mortality worldwide, frequently occurs early in the diagnosis of lung adenocarcinoma (LUAD). However, the precise molecular mechanisms governing the aggressive metastatic behavior of LUAD remain incompletely understood. In this study, we present compelling evidence indicating that the long noncoding RNA linc01703 is significantly downregulated in metastatic lung cancer cells. Intriguingly, in vivo experiments revealed that Linc01703 exerted a profound inhibitory effect on lung cancer metastasis without discernible impact on the in vitro proliferation or invasion capacities of LUAD cells. Mechanistically, Linc01703 enhanced the interaction between Rab27a, SYTL1, and CD81, consequently promoting the secretion of CD81

Indexed as

CD81exosomeslong noncoding RNAlung cancermetastasis

Identifiers

PMID38136327
PMCPMC10742068
OpenAlexW4389545848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.