Evidence map›Paper›PMID 38135805›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2024

Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion.

Allana Brunna Sucupira Duarte, Yunierkis Perez-Castillo, Danielle da Nóbrega Alves, Ricardo Dias de Castro, Rafael Limongi de Souza, Damião Pergentino de Sousa, Elquio Eleamen Oliveira

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Allana Brunna Sucupira DuartePost Graduation Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa, Brazil.
Yunierkis Perez-CastilloBio-Cheminformatics Research Group and Escuela de Ciencias Físicas y Matemáticas, Universidad de Las Américas, Quito, Ecuador.
Danielle da Nóbrega AlvesLaboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil.
Ricardo Dias de CastroLaboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil.
Rafael Limongi de SouzaLaboratory of Synthesis and Drug Delivery, State University of Paraíba, João Pessoa, Brazil.
Damião Pergentino de SousaDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Brazil.
Elquio Eleamen OliveiraLaboratory of Synthesis and Drug Delivery, State University of Paraíba, João Pessoa, Brazil. elquioeleamen@yahoo.com.br.ORCID http://orcid.org/0000-0002-7214-4455
Universidade Federal da Paraíba · BRUniversidade Estadual da Paraíba · BRUniversidad de Las Américas · EC

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Apoio à Pesquisa do Estado da Paraíba 001
6 · The paper itself

Abstract

The objective of this study was to evaluate the antifungal activity of free methyl 3,5 dinitrobenzoate (MDNB) and its nanoemulsion (MDNB-NE) against strains of Candida albicans. Additionally, a molecular modeling study was also carried out to propose the mechanism of action and toxicity of MDNB. These results demonstrated the MDNB-NE presented a droplet size of 181.16 ± 3.20 nm and polydispersity index of 0.30 ± 0.03. MDNB and MDNB-NE inhibited the growth of all strains with minimum inhibitory concentrations of 0.27-1.10 mM. The biological results corroborated the molecular model, which pointed to a multi-target antifungal mechanism of action for MDNB in C. albicans. The study could serve as a basis for further research involving compounds with nitro groups with antifungal.

Indexed as

Antifungal AgentsCandida albicansNitrobenzoatesMicrobial Sensitivity Tests3,5-dinitrobenzoic acidAntifungal AgentsNitrobenzoates3,5-dinitrobenzoic acidAntifungal activityCandida albicansMolecular dockingNanoemulsion

Identifiers

PMID38135805
PMCPMC10920570
OpenAlexW4390144366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.