Evidence map›Paper›PMID 38135719›Full record

ArticleNature nanotechnology2024

3D spatiotemporally scalable in vivo neural probes based on fluorinated elastomers.

Paul Le Floch, Siyuan Zhao, Ren Liu, Nicola Molinari, Eder Medina, Hao Shen, Zheliang Wang, Junsoo Kim, Hao Sheng, Sebastian Partarrieu and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Design, Construction, and Application of Implantable Fiber Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  6. Multiscale Manufacturing of Organic Electronic Materials.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. "Tone-Arm" Neuromodulation MEMS Microcoil for In Vivo Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Cell-Stress-Free Percutaneous Bioelectrodes.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 1 country.

Paul Le Floch *John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-7211-1699
Siyuan Zhao *John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0002-2658-3414
Ren Liu *John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Nicola MolinariJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Eder MedinaJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Hao ShenJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-8410-5747
Zheliang WangDepartment of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX, USA.
Junsoo KimJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-7340-2770
Hao ShengJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-7477-7830
Sebastian PartarrieuJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-6846-060X
Wenbo WangJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0002-4282-2542
Chanan SesslerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Guogao ZhangJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-5570-4062
Hyunsu ParkAxoft, Inc., Cambridge, MA, USA.
Xian GongAxoft, Inc., Cambridge, MA, USA.ORCID 0000-0003-4570-8080
Andrew SpencerAxoft, Inc., Cambridge, MA, USA.
Jongha LeeAxoft, Inc., Cambridge, MA, USA.
Tianyang YeAxoft, Inc., Cambridge, MA, USA.
Xin TangJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0002-1533-2580
Xiao WangBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3090-9894
Katia BertoldiJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Nanshu LuDepartment of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-3595-3851
Boris KozinskyJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0002-0638-539X
Zhigang SuoJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0002-4068-4844
Jia LiuJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA. jia_liu@seas.harvard.edu.ORCID 0000-0003-2217-6982
Harvard University · USBroad Institute · USThe University of Texas at Austin · US

Funding

National Science Foundation (NSF) DMR-2011754
6 · The paper itself

Abstract

Electronic devices for recording neural activity in the nervous system need to be scalable across large spatial and temporal scales while also providing millisecond and single-cell spatiotemporal resolution. However, existing high-resolution neural recording devices cannot achieve simultaneous scalability on both spatial and temporal levels due to a trade-off between sensor density and mechanical flexibility. Here we introduce a three-dimensional (3D) stacking implantable electronic platform, based on perfluorinated dielectric elastomers and tissue-level soft multilayer electrodes, that enables spatiotemporally scalable single-cell neural electrophysiology in the nervous system. Our elastomers exhibit stable dielectric performance for over a year in physiological solutions and are 10,000 times softer than conventional plastic dielectrics. By leveraging these unique characteristics we develop the packaging of lithographed nanometre-thick electrode arrays in a 3D configuration with a cross-sectional density of 7.6 electrodes per 100 µm

Indexed as

BrainElastomersAnimalsCross-Sectional StudiesElectrodesMiceNeuronsElastomers

Identifiers

PMID38135719
OpenAlexW4390113532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.