ArticlePain management nursing : official journal of the American Society of Pain Management Nurses2024
Differential Gene Expression in Pain-Related Genes are not Affected by the Presence of Dementia.
Article in Pain management nursing : official journal of the American Society of Pain Management Nurses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Pain Assessment and Management Among Nursing Home Residents Living With Dementia.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026Article
- Preliminary Evidence Supporting Validity and Reliability of the Assessment for Appropriate Use of Opioids for Long-Term Care.The Senior care pharmacist · 2025Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrior work has demonstrated differences in the transcriptome between those with and without chronic musculoskeletal pain.
aimsThe aim of this study was to explore whether pain-related gene expression is similar between individuals with and without dementia.
designThis was a descriptive study using a one-time assessment. SETTINGS: PARTICIPANTS/SUBJECTS: A total of 20 older adults living in a continuing care retirement community, 50% of whom had dementia were inlcuded in this study. All were female and the mean age of participants was 89 (SD = 6).
methodsPain was evaluated based on the PROMIS Pain Intensity Short Form 3a. Whole blood was collected by venipuncture into Tempus vacutainer tubes (3 ml) and the RNA was extracted at the Translational Genomics Laboratory at the University of Maryland Baltimore. Analyses included a differential expression analysis, a weighted gene co-expression network analysis, and a pathway enrichment analysis.
resultsEighty-three genes were differentially expressed between individuals with and without pain (p <.05). After normalizing gene counts and removing the low expressed genes, 18,028 genes were left in the final analysis. There was no clustering of the samples related to study variables of pain or dementia.
conclusionThe findings from this study provided some preliminary support that pain-related gene expression is similar between individuals with and without dementia.
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Registered trials
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