Evidence map›Paper›PMID 38135556›Full record

ArticleThe Lancet. Digital health2024

Deep learning for [

Ida Häggström, Doris Leithner, Jennifer Alvén, Gabriele Campanella, Murad Abusamra, Honglei Zhang, Shalini Chhabra, Lucian Beer, Alexander Haug, Gilles Salles and 7 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in The Lancet. Digital health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06829147 (Development and Validation of a Deep Learning Model for Diagnosing Lymph Node Metastasis in Nasopharyngeal Carcinoma Using Histologic Whole Slide Images and Time-dependent Magnetic Resonance Images), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06829147 recruitingnot on this map

Development and Validation of a Deep Learning Model for Diagnosing Lymph Node Metastasis in Nasopharyngeal Carcinoma Using Histologic Whole Slide Images and Time-dependent Magnetic Resonance Images

TypeobservationalSponsorSun Yat-sen UniversityRan2024 to 2026Enrolled500ConditionsNasopharyngeal Cancinoma (NPC), Lymph Node Metastasis
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Guideline
  2. Diagnostic Value ofTechnology in cancer research & treatment
    Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. coPERCIST: AI-assisted PET-CT response assessment.European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Clinical scoring systems, molecular subtypes and baseline [Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Ida HäggströmDepartment of Electrical Engineering, Chalmers University of Technology, Gothenburg, Sweden; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Doris LeithnerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Radiology, NYU Langone Health, Grossman School of Medicine, New York, NY, USA.
Jennifer AlvénDepartment of Electrical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Gabriele CampanellaHasso Plattner Institute for Digital Health, Mount Sinai Medical School, New York, NY, USA; Department of AI and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Murad AbusamraDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Honglei ZhangDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Shalini ChhabraDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lucian BeerDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Alexander HaugDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Gilles SallesDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, Cornell University, New York, NY, USA.
Markus RadererDepartment of Medicine I, Medical University of Vienna, Vienna, Austria.
Philipp B StaberDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Anton BeckerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, Cornell University, New York, NY, USA; Department of Radiology, NYU Langone Health, Grossman School of Medicine, New York, NY, USA.
Hedvig HricakDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, Cornell University, New York, NY, USA.
Thomas J FuchsHasso Plattner Institute for Digital Health, Mount Sinai Medical School, New York, NY, USA; Department of AI and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, Cornell University, New York, NY, USA.
Marius E MayerhoeferDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Weill Cornell Medical College, Cornell University, New York, NY, USA; Department of Radiology, NYU Langone Health, Grossman School of Medicine, New York, NY, USA. Electronic address: marius.mayerhoefer@nyulangone.org.
Memorial Sloan Kettering Cancer Center · USMedical University of Vienna · ATCornell University · USChalmers University of Technology · SEIcahn School of Medicine at Mount Sinai · USMount Sinai Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThe rising global cancer burden has led to an increasing demand for imaging tests such as [

methodsIn this retrospective analysis we collected 16 583 [

findingsIn the internal test cohort (3325 PET-CTs, 1012 patients), LARS-avg achieved an AUC of 0·949 (95% CI 0·942-0·956), accuracy of 0·890 (0·879-0·901), sensitivity of 0·868 (0·851-0·885), and specificity of 0·913 (0·899-0·925); LARS-max achieved an AUC of 0·949 (0·942-0·956), accuracy of 0·868 (0·858-0·879), sensitivity of 0·909 (0·896-0·924), and specificity of 0·826 (0·808-0·843); and LARS-ptct achieved an AUC of 0·939 (0·930-0·948), accuracy of 0·875 (0·864-0·887), sensitivity of 0·836 (0·817-0·855), and specificity of 0·915 (0·901-0·927). In the external test cohort (1000 PET-CTs, 503 patients), LARS-avg achieved an AUC of 0·953 (0·938-0·966), accuracy of 0·907 (0·888-0·925), sensitivity of 0·874 (0·843-0·904), and specificity of 0·949 (0·921-0·960); LARS-max achieved an AUC of 0·952 (0·937-0·965), accuracy of 0·898 (0·878-0·916), sensitivity of 0·899 (0·871-0·926), and specificity of 0·897 (0·871-0·922); and LARS-ptct achieved an AUC of 0·932 (0·915-0·948), accuracy of 0·870 (0·850-0·891), sensitivity of 0·827 (0·793-0·863), and specificity of 0·913 (0·889-0·937).

interpretationDeep learning accurately distinguishes between [

fundingNational Institutes of Health-National Cancer Institute Cancer Center Support Grant.

Indexed as

Deep LearningLymphomaArtificial IntelligenceFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyRadiopharmaceuticalsRetrospective StudiesUnited StatesFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID38135556
PMCPMC10972536
OpenAlexW4390042884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.