Trial reportArchives of disease in childhood. Fetal and neonatal edition2024
Early and exclusive enteral nutrition in infants born very preterm.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04337710 (Exclusive Enteral Nutrition in Preterm Neonates- A Randomized Controlled Trial), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exclusive Enteral Nutrition in Preterm Neonates- A Randomized Controlled Trial
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Early full or near-full enteral feeding in clinically stable preterm infants across healthcare settings: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Early total enteral feeding versus conventional incremental feeding in preterm infants weighing 1000-1250 g: a single-center open-label randomized controlled trial.European journal of pediatrics · 2026Trial
- Early gut microbiome composition of very preterm infants randomised to receive human milk volumes of 60 ml/kg/day or more within the first 36 hours after birth.Pediatric research · 2026Trial
- Cost-consequence analysis of early full milk feeding versus gradual feeding with intravenous support in preterm infants: results from the FEED1 trial.Archives of disease in childhood. Fetal and neonatal edition · 2026Trial
- Early full enteral nutrition with fortified milk in very preterm infants: a randomized clinical trial.The American journal of clinical nutrition · 2025Trial
- Effects of rapid enteral feed advancement with early human milk fortification in very low birth weight preterm infants > 30 weeks gestation in a resource limited setting- a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Bedside ultrasound imaging to measure muscle cross-sectional area in preterm and term infants: a feasibility study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- The impact of central venous catheter use on long-term growth and neurobehavioral outcome in preterm children born < 29 weeks of gestation.Molecular and cellular pediatrics · 2026Article
- Enteral nutrition in neonates: current evidence from clinical trials and evolving strategies.Seminars in perinatology · 2026Review
- Early feeding and fluid volume associations with adverse in-hospital outcomes among premature newborns.Pediatric research · 2026Article
- Neonatal steroid exposure and body composition in preterm infants at discharge.Pediatric research · 2026Article
- Effects of prenatal maternal smoking on placental IGF-1, leptin, and HPL expression and breastfeeding practices.BMC pregnancy and childbirth · 2026Article
- Enteral nutrition practices and associated outcomes in preterm infants with a gestational age less than 34 weeks: a single-center retrospective study.Frontiers in nutrition · 2026Article
- Turkish neonatal nurses' knowledge regarding the enteral feeding in preterm infants: a descriptive, cross-sectional study.BMC nursing · 2025Article
- Recommended nutrition for preterm infants-on track, but more research is needed.Pediatric research · 2025Article
- Exclusive enteral nutrition in preterm infants: How early is too early?Seminars in fetal & neonatal medicine · 2025Review
- Evaluation of First-Week Fluid Intake and Maximal Weight Loss Percentage with In-Hospital Adverse Outcomes Among Moderately and Very Preterm Newborns in Ethiopia.Children (Basel, Switzerland) · 2025Article
- Does early high-volume enteral feeding initiation increase the total days on full feeds in very preterm infants?Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Association between postoperative feeding patterns and gastrointestinal function reconstruction after congenital intestinal atresia in neonates.World journal of gastrointestinal surgery · 2025Article
- Standardizing feeding strategies for preterm infants born greater than 1500 grams.Pediatric research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo characterise the effects of early and exclusive enteral nutrition with either maternal or donor milk in infants born very preterm (28
designParallel-group, unmasked randomised controlled trial.
settingRegional, tertiary neonatal intensive care unit.
participants102 infants born very preterm between 2021 and 2022 (51 in each group).
interventionInfants randomised to the intervention group received 60-80 mL/kg/day within the first 36 hours after birth. Infants randomised to the control group received 20-30 mL/kg/day (standard trophic feeding volumes).
main outcome measuresThe primary outcome was the number of full enteral feeding days (>150 mL/kg/day) in the first 28 days after birth. Secondary outcomes included growth and body composition at the end of the first two postnatal weeks, and length of hospitalisation.
resultsThe mean birth weight was 1477 g (SD: 334). Half of the infants were male, and 44% were black. Early and exclusive enteral nutrition increased the number of full enteral feeding days (+2; 0-2 days; p=0.004), the fat-free mass-for-age z-scores at postnatal day 14 (+0.5; 0.1-1.0; p=0.02) and the length-for-age z-scores at the time of hospital discharge (+0.6; 0.2-1.0; p=0.002). Hospitalisation costs differed between groups (mean difference favouring the intervention group: -$28 754; -$647 to -$56 861; p=0.04).
conclusionsIn infants born very preterm, early and exclusive enteral nutrition increases the number of full enteral feeding days. This feeding practice may also improve fat-free mass accretion, increase length and reduce hospitalisation costs. TRIAL REGISTRATION NUMBER: NCT04337710.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.