Evidence map›Paper›PMID 38135359›Full record

ArticleBrain stimulation

Stereo-EEG-guided network modulation for psychiatric disorders: Interactive holographic planning.

Angela M Noecker, Jeffrey Mlakar, Kelly R Bijanki, Mark A Griswold, Nader Pouratian, Sameer A Sheth, Cameron C McIntyre

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03437928 (Deep Brain Stimulation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03437928 narecruitingnot on this map

Deep Brain Stimulation (DBS) for Depression Using Directional Current Steering and Individualized Network Targeting

TypeinterventionalSponsorBaylor College of MedicineRan2019 to 2026Enrolled12ConditionsMajor Depressive DisorderArmsDirectional Deep Brain Stimulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angela M NoeckerDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Jeffrey MlakarInteractive Commons, Case Western Reserve University, Cleveland, OH, USA.
Kelly R BijankiDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Mark A GriswoldInteractive Commons, Case Western Reserve University, Cleveland, OH, USA; Department of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Nader PouratianDepartment of Neurosurgery, University of Texas Southwestern, Dallas, TX, USA.
Sameer A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Cameron C McIntyreDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Neurosurgery, Duke University, Durham, NC, USA. Electronic address: cameron.mcintyre@duke.edu.

Funding

Deep brain stimulation for depression using directional current steering an individualized network targetingUH3NS103549 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOODMAN, WAYNE K, POURATIAN, NADER · 2017 to 2025
$8.7M
Intracranial Investigation of Neural Circuity Underlying Human MoodR01MH130597 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI Kelly Rowe Bijanki, Zachary Samuel Pitkow · 2023 to 2026
$3.5M
Mapping and Modulating the Spatiotemporal dynamics of socio-affective processing.R01MH127006 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI BIJANKI, KELLY ROWE · 2021 to 2025
$3.2M
Augmented Reality Platform for Deep Brain StimulationR01NS105690 · NINDS · DUKE UNIVERSITY · PI MCINTYRE, CAMERON · 2018 to 2022
$2.2M
Application of Advanced Imaging and Visualization to Clinical Deep Brain StimulationR37NS116079 · NINDS · DUKE UNIVERSITY · PI MCINTYRE, CAMERON · 2021 to 2025
$1.8M
COGNITIVE CONTROL MECHANISMS IN HUMAN PREFRONTAL CORTEXR01MH106700 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHETH, SAMEER ANIL · 2016 to 2020
$1.6M
NIMH NIH HHS R01 MH106700NIMH NIH HHS R01 MH127006NIMH NIH HHS R01 MH130597NINDS NIH HHS R01 NS105690NINDS NIH HHS R37 NS116079NINDS NIH HHS UH3 NS103549
6 · The paper itself

Abstract

backgroundConnectomic modeling studies are expanding understanding of the brain networks that are modulated by deep brain stimulation (DBS) therapies. However, explicit integration of these modeling results into prospective neurosurgical planning is only beginning to evolve. One challenge of employing connectomic models in patient-specific surgical planning is the inherent 3D nature of the results, which can make clinically useful data integration and visualization difficult.

methodsWe developed a holographic stereotactic neurosurgery research tool (HoloSNS) that integrates patient-specific brain models into a group-based visualization environment for interactive surgical planning using connectomic hypotheses. HoloSNS currently runs on the HoloLens 2 platform and it enables remote networking between headsets. This allowed us to perform surgical planning group meetings with study co-investigators distributed across the country.

resultsWe used HoloSNS to plan stereo-EEG and DBS electrode placements for each patient participating in a clinical trial (NCT03437928) that is targeting both the subcallosal cingulate and ventral capsule for the treatment of depression. Each patient model consisted of multiple components of scientific data and anatomical reconstructions of the head and brain (both patient-specific and atlas-based), which far exceed the data integration capabilities of traditional neurosurgical planning workstations. This allowed us to prospectively discuss and evaluate the positioning of the electrodes based on novel connectomic hypotheses.

conclusionsThe 3D nature of the surgical procedure, brain imaging data, and connectomic modeling results all highlighted the utility of employing holographic visualization to support the design of unique clinical experiments to explore brain network modulation with DBS.

Indexed as

Deep Brain StimulationMental DisordersBrainElectroencephalographyHumansProspective StudiesDBSDepressionHoloLenssEEGVisualization

Identifiers

PMID38135359
PMCPMC10784872

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.