Evidence map›Paper›PMID 38135163›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2024

A role for decorin in improving motor deficits after traumatic brain injury.

Kaori Oshima, Noah Siddiqui, James E Orfila, Danelle Carter, Justin Laing, Xiaorui Han, Igor Zakharevich, Renato V Iozzo, Arsen Ghasabyan, Hunter Moore and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Kaori OshimaDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Noah SiddiquiDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
James E OrfilaDepartment of Neurosurgery, The Ohio State University, College of Medicine, Columbus, Ohio, USA.
Danelle CarterDepartment of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Justin LaingDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Xiaorui HanDepartments of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA; Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
Igor ZakharevichDepartment of Biochemistry, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
Renato V IozzoDepartment of Pathology and Genomic Medicine and the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Arsen GhasabyanDepartment of Surgery, Ernest E. Moore Shock Trauma Center at Denver Health, University of Colorado, Denver, Colorado, USA.
Hunter MooreDepartment of Surgery, Ernest E. Moore Shock Trauma Center at Denver Health, University of Colorado, Denver, Colorado, USA.
Fuming ZhangDepartments of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA.
Robert J LinhardtDepartments of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA.
Ernest E MooreDepartment of Surgery, Ernest E. Moore Shock Trauma Center at Denver Health, University of Colorado, Denver, Colorado, USA.
Nidia QuillinanDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Eric P SchmidtDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Paco S HersonDepartment of Neurosurgery, The Ohio State University, College of Medicine, Columbus, Ohio, USA.
Joseph A HippensteelDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: joseph.hippensteel@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USDenver Health Medical Center · USRensselaer Polytechnic Institute · USHarvard University · USThe Ohio State University · USThomas Jefferson University · US

Funding

NEOPLASTIC MODULATION OF PROTEOGLYCAN METABOLISMR01CA039481 · NCI · UNIVERSITY OF PENNSYLVANIA · PI IOZZO, RENATO V. · 1985 to 2020
$7.1M
Proteoglycan regulation of tumor angiogenesis and endothelial cell autophagyR01CA245311 · NCI · THOMAS JEFFERSON UNIVERSITY · PI IOZZO, RENATO V. · 2020 to 2024
$2.0M
Lung-Brain Axis as a Mediator of DeliriumK08HL159353 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HIPPENSTEEL, JOSEPH ALAN · 2021 to 2025
$809k
Endothelial Glycocalyx Degradation during Sepsis in AgingR03AG074056 · NIA · UNIVERSITY OF COLORADO DENVER · PI HIPPENSTEEL, JOSEPH ALAN · 2021 to 2022
$311k
Mitostatin-evoked mitophagy for breast cancer inhibitionR03CA270830 · NCI · THOMAS JEFFERSON UNIVERSITY · PI IOZZO, RENATO V. · 2023 to 2024
$156k
American Heart Association Career Development Award 932840NCI NIH HHS R01 CA039481NCI NIH HHS R01 CA245311NCI NIH HHS R03 CA270830NHLBI NIH HHS K08 HL159353NIA NIH HHS R03 AG074056
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is the leading cause of death and disability due to injury worldwide. Extracellular matrix (ECM) remodeling is known to significantly contribute to TBI pathophysiology. Glycosaminoglycans, which are long-chain, variably sulfated polysaccharides abundant within the ECM, have previously been shown to be substantially altered after TBI. In this study, we sought to delineate the dynamics of glycosaminoglycan alterations after TBI and discover the precise biologic processes responsible for observed glycosaminoglycan changes after injury. We performed state-of-the art mass spectrometry on brain tissues isolated from mice after TBI or craniotomy-alone. We observed dynamic changes in glycosaminoglycans at Day 1 and 7 post-TBI, with heparan sulfate, chondroitin sulfate, and hyaluronan remaining significantly increased after a week vis-à-vis craniotomy-alone tissues. We did not observe appreciable changes in circulating glycosaminoglycans in mice after experimental TBI compared to craniotomy-alone nor in patients with TBI and severe polytrauma compared to control patients with mild injuries, suggesting increases in injury site glycosaminoglycans are driven by local synthesis. We subsequently performed an unbiased whole genome transcriptomics analysis on mouse brain tissues 7 days post-TBI and discovered a significant induction of hyaluronan synthase 2, glypican-3, and decorin. The functional role of decorin after injury was further examined through multimodal behavioral testing comparing wild-type and Dcn

Indexed as

Brain Injuries, TraumaticGlycosaminoglycansAnimalsChondroitin SulfatesDecorinExtracellular Matrix ProteinsHumansMiceChondroitin SulfatesDcn protein, mouseDecorinExtracellular Matrix ProteinsGlycosaminoglycansDecorinExtracellular matrixGlycosaminoglycansGlypican 3Hyaluronan SynthasePolytraumaProteoglycansTraumatic brain injury

Identifiers

PMID38135163
PMCPMC10922985
OpenAlexW4390052300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.