Evidence map›Paper›PMID 38135096›Full record

ArticleProgress in neuro-psychopharmacology & biological psychiatry2024

Cannabinoid CB2 receptors and hypersensitivity to methamphetamine: Vulnerability to schizophrenia.

Ana Canseco-Alba, Koichi Tabata, Yukihiko Momoki, Taharima Tabassum, Yasue Horiuchi, Tadao Arinami, Emmanuel S Onaivi, Hiroki Ishiguro

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in neuro-psychopharmacology & biological psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ana Canseco-AlbaLaboratory of Reticular Formation Physiology, National Institute of Neurology and Neurosurgery, Mexico City 14269, Mexico; Department of Biology, William Paterson University, Wayne, NJ 07470, USA.
Koichi TabataDepartment of Neuropsychiatry, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi 409-3821, Japan.
Yukihiko MomokiDepartment of Neuropsychiatry, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi 409-3821, Japan.
Taharima TabassumDepartment of Clinical Genetics, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi 409-3821, Japan.
Yasue HoriuchiDepartment of Clinical Genetics, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi 409-3821, Japan; Department of Genomic Medicine, Shizuoka Graduate University of Public Health, Shizuoka, Shizuoka 420-0881, Japan.
Tadao ArinamiDepartment of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Yamanashi, Chuo, Yamanashi 409-3821, Japan.
Emmanuel S OnaiviDepartment of Biology, William Paterson University, Wayne, NJ 07470, USA.
Hiroki IshiguroDepartment of Neuropsychiatry, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi 409-3821, Japan; Department of Clinical Genetics, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi 409-3821, Japan. Electronic address: hishiguro@yamanashi.ac.jp.
University of Yamanashi · JPInstituto Nacional de Neurología y Neurocirugía · MXWilliam Paterson University · US

Funding

Neuroimmune behaviorial effects of CB2 cannabinoid receptorsR15AA027909 · NIAAA · WILLIAM PATERSON UNIVERSITY · PI ONAIVI, EMMANUEL S · 2020 to 2020
$412k
BEHAVIORAL EFFECTS OF CB2 CANNABINOID RECEPTORS (CB2RS)R15DA032890 · NIDA · WILLIAM PATERSON UNIVERSITY · PI ONAIVI, EMMANUEL S · 2012 to 2012
$352k
NIAAA NIH HHS R15 AA027909NIDA NIH HHS R15 DA032890
6 · The paper itself

Abstract

The human cannabinoid receptor 2 (CB2R) gene CNR2 has been associated with schizophrenia development. Inbred mice treated with the CB2R inverse agonist AM630 and challenged with methamphetamine (MAP) showed reduced prepulse inhibition (%PPI) response and locomotor hyperactivity, both behavioral measures in rodents that correlate with psychosis. Mice lacking CB2R on striatal dopaminergic neurons exhibit a hyperdopaminergic tone and a hyperactivity phenotype. Hyperdopaminergia plays a role in the etiology of schizophrenia. This study aimed to determine the direct role of CB2R, heterozygous Cnr2 gene knockout (Het) mice treated with MAP to induce behavioral sensitivity mimicking a schizophrenia-like human phenotype. Additionally, the study aims to explore the unique modulation of dopamine activity by neuronal CB2R. Conditional knockout DAT-Cnr2

Indexed as

CannabinoidsMethamphetamineSchizophreniaAnimalsDrug Inverse AgonismHumansMiceMice, Inbred C57BLMice, KnockoutReceptor, Cannabinoid, CB2Receptors, CannabinoidCannabinoidsMethamphetamineReceptor, Cannabinoid, CB2Receptors, CannabinoidCannabinoid CB2 receptorDopaminergic neuronMethamphetamineSchizophrenia

Identifiers

PMID38135096
PMCPMC10872318
OpenAlexW4389990288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.