Evidence map›Paper›PMID 38134927›Full record

ArticleStem cell reports2024

Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems.

Surat Parvatam, David Pamies, Francesca Pistollato, Sonja Beken, Indumathi Mariappan, Adrian Roth, Monica Piergiovanni, Benoît G C Maisonneuve, Lorna Ewart, Abhijit Majumder and 5 more

Abstract read
In one paragraph

Article in Stem cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Surat ParvatamHumane Society International, Hyderabad, India. Electronic address: sparvatam@hsi.org.
David PamiesSCAHT - Swiss Centre for Applied Human Toxicology. University of Basel. Missionsstrasse 64, 4055 Basel, Switzerland.
Francesca PistollatoHumane Society International, Rue Belliard 40, 1040 Bruxelles, Belgium.
Sonja BekenFederal Agency for Medicines and Health Products, Brussels, Belgium.
Indumathi MariappanCenter for Ocular Regeneration, LV Prasad Eye Institute, Hyderabad, India.
Adrian RothF. Hoffmann-La Roche, Basel, Switzerland.
Monica PiergiovanniEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.
Benoît G C MaisonneuveNETRI, Lyon, France.
Lorna EwartEmulate Inc, 27 Drydock Avenue, Boston, MA, USA.
Abhijit MajumderIndian Institute of Technology Bombay (IITB), Mumbai, India.
Prajakta DandekarInstitute of Chemical Technology, Mumbai, India.
Rahul DateJai Research Foundation, Gujarat, India.
Kasturi MahadikCentre for Predictive Human Model Systems, Atal Incubation Centre-Centre for Cellular and Molecular Biology (AIC-CCMB), Hyderabad, India.
Saravanan ThiyagarajanAurigene Oncology Limited, Bangalore, India.
Sandra CoeckeEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With a recent amendment, India joined other countries that have removed the legislative barrier toward the use of human-relevant methods in drug development. Here, global stakeholders weigh in on the urgent need to globally harmonize the guidelines toward the standardization of microphysiological systems. We discuss a possible framework for establishing scientific confidence and regulatory approval of these methods.

Indexed as

Microphysiological SystemsPolicyDrug DevelopmentHumans

Identifiers

PMID38134927
PMCPMC10828677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.