Evidence map›Paper›PMID 38134715›Full record

ArticleJournal of critical care2024

Prevalence of frailty and association with patient centered outcomes: A prospective registry-embedded cohort study from India.

Bharath Kumar Tirupakuzhi Vijayaraghavan, Aasiyah Rashan, Lakshmi Ranganathan, Ramesh Venkataraman, Swagata Tripathy, Devachandran Jayakumar, Pratheema Ramachandran, Zubair Umer Mohamed, Sindhu Balakrishnan, Nagarajan Ramakrishnan and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Impact of the Clinical Frailty Score on Outcomes of Critically Ill Patients in a Tertiary Care ICU.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 6 countries.

Bharath Kumar Tirupakuzhi VijayaraghavanDepartment of Critical Care Medicine, Apollo Hospitals, Chennai, India; The George Institute for Global Health, New Delhi, India. Electronic address: bharath@icuconsultants.com.
Aasiyah RashanNetwork for Improving Critical care Systems and Training, Colombo, Sri Lanka; University College, London.
Lakshmi RanganathanDepartment of Critical Care Medicine, Apollo Hospitals, Chennai, India.
Ramesh VenkataramanDepartment of Critical Care Medicine, Apollo Hospitals, Chennai, India.
Swagata TripathyDepartment of Anaesthesia and Critical Care Medicine, All India Institute of Medical Sciences, Bhubaneswar, India.
Devachandran JayakumarDepartment of Critical Care Medicine, Apollo Specialty Hospital, Chennai, India; Department of Critical Care Medicine, Dr. Kamakshi Memorial Hospital, Chennai, India.
Pratheema RamachandranDepartment of Critical Care Medicine, Apollo Specialty Hospital, Chennai, India.
Zubair Umer MohamedDepartment of Anaesthesia and Critical Care Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, India.
Sindhu BalakrishnanDepartment of Anaesthesia and Critical Care Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, India.
Nagarajan RamakrishnanDepartment of Critical Care Medicine, Apollo Hospitals, Chennai, India.
Rashan HaniffaMahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand; Centre for Inflammation Research, University of Edinburgh, United Kingdom.
Abi BeaneMahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand; Centre for Inflammation Research, University of Edinburgh, United Kingdom.
Neill K J AdhikariInterdepartmental Division of Critical Care Medicine, University of Toronto, Canada; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.
Nicolette de KeizerDepartment of Medical Informatics, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
Nazir LoneUsher Institute, University of Edinburgh, Edinburgh, United Kingdom.
IRIS collaborative
Apollo Hospitals · INAmrita Institute of Medical Sciences and Research Centre · INAll India Institute of Medical Sciences Bhubaneswar · INAmsterdam University Medical Centers · NLApollo Hospitals · INCentre for Inflammation Research · GBDr. Kamakshi Memorial Hospital · INMahidol Oxford Tropical Medicine Research Unit · THSunnybrook Health Science Centre · CAUniversity College London · GBUniversity of Edinburgh · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

purposeWe aimed to study the prevalence of frailty, evaluate risk factors, and understand impact on outcomes in India.

methodsThis was a prospective registry-embedded cohort study across 7 intensive care units (ICUs) and included adult patients anticipated to stay for at least 48 h. Primary exposure was frailty, as defined by a score ≥ 5 on the Clinical Frailty Scale and primary outcome was ICU mortality. Secondary outcomes included in-hospital mortality and resource utilization. We used generalized linear models to evaluate risk factors and model association between frailty and outcomes.

results838 patients were included, with median (IQR) age 57 (42,68) yrs.; 64.8% were male. Prevalence of frailty was 19.8%. Charlson comorbidity index (OR:1.73 (95%CI:1.39,2.15)), Subjective Global Assessment categories mild/moderate malnourishment (OR:1.90 (95%CI:1.29, 2.80)) and severe malnourishment (OR:4.76 (95% CI:2.10,10.77)) were associated with frailty. Frailty was associated with higher odds of ICU mortality (adjusted OR:2.04 (95% CI:1.25,3.33)), hospital mortality (adjusted OR:2.36 (95%CI:1.45,3.84)), development of stage2/3 AKI (unadjusted OR:2.35 (95%CI:1.60, 3.43)), receipt of non-invasive ventilation (unadjusted OR:2.68 (95%CI:1.77, 4.03)), receipt of vasopressors (unadjusted OR:1.47 (95%CI:1.04, 2.07)), and receipt of kidney replacement therapy (unadjusted OR:3.15 (95%CI:1.90, 5.17)).

conclusionsFrailty is common among critically ill patients in India and is associated with worse outcomes. STUDY REGISTRATION: CTRI/2021/02/031503.

Indexed as

FrailtyMalnutritionAdultCohort StudiesCritical IllnessFemaleHospital MortalityHumansIntensive Care UnitsMaleMiddle AgedPatient-Centered CarePrevalenceRegistriesDeveloping countriesFrailtyGlobal HealthIntensive care unitsRegistries

Identifiers

PMID38134715
PMCPMC10830405
OpenAlexW4390044935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.