ArticleScience advances2023
Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer.
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Targeting CDK4/6 potentiates the efficacy of anti-CD47 therapy via modulating the suppressive function of tumor-associated macrophages.Apoptosis : an international journal on programmed cell death · 2026Article
- Enhanced exosomes for fertility protection against chemotherapy-induced ovarian damage.NPJ Regenerative medicine · 2026Article
- Spatial single-cell profiling identifies protein kinase Cδ-expressing microglia with anti-tumor function in glioblastoma.iScience · 2026Article
- Targeting SPAK suppresses progression and averts an immune exhaustive microenvironment in hepatocellular carcinoma.Nature communications · 2026Article
- Research on the correlation and potential mechanism of PKCδ expression with efficacy and prognosis in diffuse large B-cell lymphoma.Frontiers in oncology · 2026Article
- Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade.bioRxiv : the preprint server for biology · 2025Article
- Regulation of selective class switching provides long-term therapeutic benefits for hay fever.JCI insight · 2025Article
- MiR-26b-5p mediates radioresistance and immunosuppression via targeting PRKCD in non-small cell lung cancer.Journal of cancer research and clinical oncology · 2025Article
- The gut microbiome enhances breast cancer immunotherapy following bariatric surgery.JCI insight · 2025Article
- Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions duringbioRxiv : the preprint server for biology · 2025Article
- Incretin triple agonist retatrutide (LY3437943) alleviates obesity-associated cancer progression.npj metabolic health and disease · 2025Article
- Novel insights and an updated review of metabolic syndrome in immune-mediated organ transplant rejection.Frontiers in immunology · 2025Review
- Protein kinase C zeta promotes thyroid Cancer progression and represents a novel therapeutic target: evidence from specific atypical PKC inhibitor 2-acetyl-1,3-cyclopentanedione inhibitor studies.Frontiers in medicine · 2025Article
- FXR Agonism with Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden.Cancers · 2024Article
- Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune Response.Biology · 2023Review
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Mehdi ChaibDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-4793-0120
Jeremiah R HoltDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-5201-5015
Emilie L FisherVanderbilt Center for Immunobiology and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37235, USA.ORCID 0000-0001-9186-7512
Laura M SipeDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-7848-3848
Margaret S BohmDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-7409-7798
Sydney C JosephDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-3606-5650
Boston W SimmonsDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-1153-7471
Samson Eugin SimonDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0003-0710-3857
Johnathan R YarbroDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-5819-2517
Ubaid TanveerDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-0002-9490
Jessica L HalleDepartment of Physical Therapy, College of Health Professions, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-3174-5713
James A CarsonDepartment of Physical Therapy, College of Health Professions, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
T J HollingsworthDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-2119-521X
QingQing WeiDepartment of Cellular Biology and Anatomy, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-1692-2451
Jeffrey C RathmellVanderbilt Center for Immunobiology and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37235, USA.ORCID 0000-0002-4106-3396
Paul G ThomasDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-7955-0256
D Neil HayesDepartment of Medicine, Division of Hematology and Oncology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-6203-7771
Liza MakowskiDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-5337-8037
University of Tennessee Health Science Center · USVanderbilt University Medical Center · USAugusta University · USSt. Jude Children's Research Hospital · US
Funding
UNITS: The UNC / UT National Clinical Trials Network Group Integrated Translational Science Production and Consultation CenterUG1CA233333 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAYES, DAVID N, MERKER, JASON DEREK · 2019 to 2025
$4.8MExploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory diseaseR01DK105550 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2015 to 2026
$4.7MMetabolic Barriers to T Cell Activation in Clear Cell Renal Cell CarcinomaR01CA217987 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2018 to 2026
$4.3MRole of microbial-modulated bile acid receptor signaling in breast cancerR01CA253329 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Katherine Loree Cook, Liza Makowski-Hayes · 2020 to 2026
$3.0MTransdisciplinary Research in Energetics and Cancer (TREC) Training GrantR25CA203650 · NCI · YALE UNIVERSITY · PI IRWIN, MELINDA L · 2016 to 2025
$2.9MObesity-driven Metabolic and Molecular Biomarkers of Metformin Response in Endometrial CancerR37CA226969 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAE-JUMP, VICTORIA LIN · 2018 to 2024
$2.5MSpecialized RNA analysis center for integrative genomic analysesU24CA264021 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAYES, DAVID N, HOADLEY, KATHERINE A. · 2021 to 2025
$1.7MThe regulation and function of long non coding RNA in ischemic AKI: Role of GSTM3P1R01DK126763 · NIDDK · AUGUSTA UNIVERSITY · PI WEI, QINGQING · 2021 to 2024
$1.3MPan-cancer genomic characterization of human papillomavirus associated tumorsF30CA265224 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HOLT, JEREMIAH R. · 2022 to 2025
$186kThe role of bile acids to ameliorate obesity driven triple negative breast cancerF32CA250192 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SIPE, LAURA MARIE · 2021 to 2022
$80kPKC agonism restricts innate immune suppression and promotes antigen cross-presentation in Triple Negative Breast CancerF31CA268871 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI CHAIB, MEHDI · 2022 to 2022
$33kNCI NIH HHS F30 CA265224NCI NIH HHS F31 CA268871NCI NIH HHS F32 CA250192NCI NIH HHS R01 CA217987NCI NIH HHS R01 CA253329NCI NIH HHS R25 CA203650NCI NIH HHS R37 CA226969NCI NIH HHS U24 CA264021NCI NIH HHS UG1 CA233333NIDDK NIH HHS R01 DK105550NIDDK NIH HHS R01 DK126763
Abstract
Mononuclear phagocytes (MPs) play a crucial role in tissue homeostasis; however, MPs also contribute to tumor progression and resistance to immune checkpoint blockade (ICB). Targeting MPs could be an effective strategy to enhance ICB efficacy. We report that protein kinase C delta (PKCδ), a serine/threonine kinase, is abundantly expressed by MPs in human and mouse tumors. PKCδ
Indexed as
NeoplasmsProtein Kinase C-deltaAnimalsHumansImmunotherapyMicePhagocytesSignal TransductionProtein Kinase C-delta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.