Evidence map›Paper›PMID 38134274›Full record

ArticleScience advances2023

Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children.

Kevin S Bonham, Guilherme Fahur Bottino, Shelley Hoeft McCann, Jennifer Beauchemin, Elizabeth Weisse, Fatoumata Barry, Rosa Cano Lorente, RESONANCE Consortium, Curtis Huttenhower, Muriel Bruchhage and 3 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  14. Gut Microbiota-Butyrate-PPARγ Axis Modulates Adipose Regulatory T Cell Population.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Kevin S BonhamDepartment of Biological Sciences, Wellesley College, Wellesley, MA, USA.ORCID 0000-0003-3200-7533
Guilherme Fahur BottinoDepartment of Biological Sciences, Wellesley College, Wellesley, MA, USA.ORCID 0000-0003-1953-1576
Shelley Hoeft McCannDepartment of Biological Sciences, Wellesley College, Wellesley, MA, USA.ORCID 0000-0002-9753-7968
Jennifer BeaucheminRhode Island Hospital, Providence, RI, USA.ORCID 0000-0003-2077-4639
Elizabeth WeisseDepartment of Psychology, University of Stavanger, Stavanger, Norway.
Fatoumata BarryRhode Island Hospital, Providence, RI, USA.
Rosa Cano LorenteRhode Island Hospital, Providence, RI, USA.ORCID 0000-0003-1971-7389
RESONANCE Consortium
Curtis HuttenhowerDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-1110-0096
Muriel BruchhageDepartment of Psychology, University of Stavanger, Stavanger, Norway.ORCID 0000-0001-9637-0951
Viren D'SaRhode Island Hospital, Providence, RI, USA.ORCID 0000-0002-3476-8419
Sean DeoniRhode Island Hospital, Providence, RI, USA.
Vanja Klepac-CerajDepartment of Biological Sciences, Wellesley College, Wellesley, MA, USA.ORCID 0000-0001-5387-5706
Providence College · USWellesley College · USUniversity of Stavanger · NOBroad Institute · US

Funding

The Developing Brain: Influences and OutcomesUH3OD023313 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI Viren Andrew D'Sa, Daphne Koinis Mitchell · 2018 to 2026
$20.7M
The Developing Brain: Influences and OutcomesUG3OD023313 · OD · UNIVERSITY OF COLORADO DENVER · PI D'SA, VIREN ANDREW, KOINIS MITCHELL, DAPHNE · 2016 to 2024
$11.6M
NIH HHS UG3 OD023313Wellcome Trust
6 · The paper itself

Abstract

Emerging evidence implicates gut microbial metabolism in neurodevelopmental disorders, but its influence on typical neurodevelopment has not been explored in detail. We investigated the relationship between the microbiome and neuroanatomy and cognition of 381 healthy children, demonstrating that differences in microbial taxa and genes are associated with overall cognitive function and the size of brain regions. Using a combination of statistical and machine learning models, we showed that species including

Indexed as

Gastrointestinal MicrobiomeNeuroanatomyBrainChildCognitionFecesHumans

Identifiers

PMID38134274
PMCPMC10745691
OpenAlexW4390099000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.