Evidence map›Paper›PMID 38134265›Full record

ArticleStroke2024

Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling.

Stephanie Hage, Serena Kinkade, Romuald Girard, Kelly D Flemming, Helen Kim, Michel T Torbey, Judy Huang, John Huston, Yunhong Shu, Reed G Selwyn and 22 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03652181 (CASH), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03652181 completednot on this map

CASH (Cavernous Angiomas With Symptomatic Hemorrhage) Trial Readiness

TypeobservationalSponsorUniversity of ChicagoRan2018 to 2022Enrolled123ConditionsCCM, Cavernoma, Cerebral Cavernous Malformation, Cerebral Cavernous Malformations 1
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Observational
  6. The Role of the Microbiome and the Neurovascular Unit.The Surgical clinics of North America · 2025
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 9 institutions in 1 country.

Stephanie HageNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.ORCID 0000-0002-8168-4621
Serena KinkadeNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.
Romuald GirardNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.
Kelly D FlemmingDepartments of Neurology (K.D.F.), Mayo Clinic, Rochester, MN.ORCID 0000-0001-6021-1190
Helen KimDepartment of Anesthesiology and Perioperative Care, Center for Cerebrovascular Research (H.K.), University of California, San Francisco.ORCID 0000-0002-1937-354X
Michel T TorbeyDepartment of Neurology (M.T.T.), University of New Mexico, Albuquerque.ORCID 0000-0001-8187-9683
Judy HuangDepartment of Neurosurgery (J.H., J.F.).ORCID 0000-0002-0675-1935
John HustonRadiology (J. Huston, Y.S.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-0584-9460
Yunhong ShuRadiology (J. Huston, Y.S.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-7521-9088
Reed G SelwynDepartment of Diagnostic Radiology (R.G.S., B.L.H.), University of New Mexico, Albuquerque.ORCID 0000-0003-4547-8342
Blaine L HartDepartment of Diagnostic Radiology (R.G.S., B.L.H.), University of New Mexico, Albuquerque.
Marc C MabrayDepartment of Radiology (M.C.M.), University of New Mexico, Albuquerque.
James FeghaliDepartment of Neurosurgery (J.H., J.F.).ORCID 0000-0001-7168-4751
Haris I SairThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD (H.I.S.).
Jared NarvidDepartment of Radiology and Biomedical Imaging (J.N., J.M.L.), University of California, San Francisco.ORCID 0000-0002-2887-4231
Janine M LupoDepartment of Radiology and Biomedical Imaging (J.N., J.M.L.), University of California, San Francisco.
Justine LeeNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.
Agnieszka StadnikNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.
Roberto J Alcazar-FelixNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.ORCID 0000-0003-1214-5576
Robert ShenkarNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.ORCID 0000-0002-1300-6845
Nicholas HobsonNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.ORCID 0000-0001-6034-8795
Dorothy DeBiasseNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.ORCID 0000-0002-4111-6750
Karen LaneBrain Injury Outcomes Unit, Department of Neurology (K.L., N.A.M., K.T., N.O., Y.W., R.E.T., D.F.H.), Johns Hopkins University Medical Institutions, Baltimore, MD.ORCID 0000-0002-7529-0714
Nichole A McBeeBrain Injury Outcomes Unit, Department of Neurology (K.L., N.A.M., K.T., N.O., Y.W., R.E.T., D.F.H.), Johns Hopkins University Medical Institutions, Baltimore, MD.
Kevin TreineBrain Injury Outcomes Unit, Department of Neurology (K.L., N.A.M., K.T., N.O., Y.W., R.E.T., D.F.H.), Johns Hopkins University Medical Institutions, Baltimore, MD.
Noeleen OstapkovichBrain Injury Outcomes Unit, Department of Neurology (K.L., N.A.M., K.T., N.O., Y.W., R.E.T., D.F.H.), Johns Hopkins University Medical Institutions, Baltimore, MD.ORCID 0000-0002-6465-2345
Ying WangBrain Injury Outcomes Unit, Department of Neurology (K.L., N.A.M., K.T., N.O., Y.W., R.E.T., D.F.H.), Johns Hopkins University Medical Institutions, Baltimore, MD.
Richard E ThompsonBrain Injury Outcomes Unit, Department of Neurology (K.L., N.A.M., K.T., N.O., Y.W., R.E.T., D.F.H.), Johns Hopkins University Medical Institutions, Baltimore, MD.
James I KoenigNational Institute of Neurological Disorders and Stroke, Bethesda, MD (J.K.).ORCID 0000-0003-1930-6870
Timothy CarrollDepartment of Diagnostic Radiology (T.C.), University of Chicago Medicine and Biological Sciences, IL.ORCID 0000-0003-2113-6284
Daniel F HanleyBrain Injury Outcomes Unit, Department of Neurology (K.L., N.A.M., K.T., N.O., Y.W., R.E.T., D.F.H.), Johns Hopkins University Medical Institutions, Baltimore, MD.ORCID 0000-0002-9536-4258
Issam A AwadNeurovascular Surgery Program, Department of Neurological Surgery (S.H., S.K., R.G., J.L., A.S., R.J.A.-F., R.S., N.H., D.D., I.A.A.), University of Chicago Medicine and Biological Sciences, IL.ORCID 0000-0003-1510-602X
Anna Needs Neuroblastoma Answers · USJohns Hopkins University · USMayo Clinic · USTwitter (United States) · USUniversity of New Mexico · USUniversity of California, San Francisco · USJDSU (United States) · USNational Institute of Neurological Disorders and Stroke · USUniversity of California System · US

Funding

Trial Readiness in Cavernous Angiomas with Symptomatic HemorrhageU01NS104157 · NINDS · UNIVERSITY OF CHICAGO · PI AWAD, ISSAM A · 2018 to 2022
$3.8M
NINDS NIH HHS U01 NS104157
6 · The paper itself

Abstract

backgroundQuantitative susceptibility mapping (QSM) and dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging sequences assessing iron deposition and vascular permeability were previously correlated with new hemorrhage in cerebral cavernous malformations. We assessed their prospective changes in a multisite trial-readiness project.

methodsPatients with cavernous malformation and symptomatic hemorrhage (SH) in the prior year, without prior or planned lesion resection or irradiation were enrolled. Mean QSM and DCEQP of the SH lesion were acquired at baseline and at 1- and 2-year follow-ups. Sensitivity and specificity of biomarker changes were analyzed in relation to predefined criteria for recurrent SH or asymptomatic change. Sample size calculations for hypothesized therapeutic effects were conducted.

resultsWe logged 143 QSM and 130 DCEQP paired annual assessments. Annual QSM change was greater in cases with SH than in cases without SH (

conclusionsAssessment of QSM change is feasible and sensitive to recurrent bleeding in cavernous malformations. Evaluation of an intervention on QSM percent change may be used as a time-averaged difference between 2 arms using a repeated measures analysis. DCEQP change is associated with lesser sensitivity and higher variability than QSM. These results are the basis of an application for certification by the US Food and Drug Administration of QSM as a biomarker of drug effect on bleeding in cavernous malformations. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03652181.

Indexed as

Hemangioma, Cavernous, Central Nervous SystemHemorrhageBiomarkersCerebral HemorrhageHumansMagnetic Resonance ImagingProspective StudiesBiomarkersbiomarkershemorrhageironperfusionpermeability

Identifiers

PMID38134265
PMCPMC10752356
OpenAlexW4390098858

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.