Evidence map›Paper›PMID 38134254›Full record

Trial reportStroke2024

Increasing Activity After Stroke: A Randomized Controlled Trial of High-Intensity Walking and Step Activity Intervention.

Elizabeth D Thompson, Ryan T Pohlig, Kiersten M McCartney, T George Hornby, Scott E Kasner, Jonathan Raser-Schramm, Allison E Miller, Christopher E Henderson, Henry Wright, Tamara Wright and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02835313 (Promoting Recovery Optimization With WALKing Exercise After Stroke), which is not on this map. Cited by 37 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 5 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02835313 nacompletednot on this map

Promoting Recovery Optimization With WALKing Exercise After Stroke

TypeinterventionalSponsorUniversity of DelawareRan2016 to 2023Enrolled250ConditionsStrokeArmsFAST alone, FAST+SAM, SAM alone
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Elizabeth D ThompsonDepartment of Physical Therapy (E.D.T., K.M.M., H.W., T.W., D.S.R.), University of Delaware, Newark.
Ryan T PohligBiostatistics Core (R.T.P.), University of Delaware, Newark.
Kiersten M McCartneyDepartment of Physical Therapy (E.D.T., K.M.M., H.W., T.W., D.S.R.), University of Delaware, Newark.ORCID 0000-0002-6304-9763
T George HornbyDepartment of Physical Medicine and Rehabilitation, Indiana University, Indianapolis (T.G.H., C.E.H.).ORCID 0000-0002-3147-3818
Scott E KasnerPerelman School of Medicine, University of Pennsylvania, Philadelphia (S.E.K.).ORCID 0000-0003-0418-6917
Jonathan Raser-SchrammChristiana Care Health System, Newark, DE (J.R.-S.).
Allison E MillerProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO (A.E.M.).ORCID 0000-0003-3043-6852
Christopher E HendersonDepartment of Physical Medicine and Rehabilitation, Indiana University, Indianapolis (T.G.H., C.E.H.).ORCID 0000-0002-9464-2789
Henry WrightDepartment of Physical Therapy (E.D.T., K.M.M., H.W., T.W., D.S.R.), University of Delaware, Newark.
Tamara WrightDepartment of Physical Therapy (E.D.T., K.M.M., H.W., T.W., D.S.R.), University of Delaware, Newark.
Darcy S ReismanDepartment of Physical Therapy (E.D.T., K.M.M., H.W., T.W., D.S.R.), University of Delaware, Newark.ORCID 0000-0002-6546-0863
University of Delaware · USIndiana University – Purdue University Indianapolis · USChristiana Care Health System · USUniversity of Pennsylvania · USWashington University in St. Louis · US

Funding

Promoting Recovery Optimization with WALKing Exercise after Stroke (PROWALKS)R01HD086362 · NICHD · UNIVERSITY OF DELAWARE · PI REISMAN, DARCY S. · 2016 to 2020
$4.0M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
NICHD NIH HHS R01 HD086362NICHD NIH HHS T32 HD007490
6 · The paper itself

Abstract

backgroundPhysical inactivity in people with chronic stroke profoundly affects daily function and increases recurrent stroke risk and mortality, making physical activity improvements an important target of intervention. We compared the effects of a high-intensity walking intervention (FAST), a step activity monitoring behavioral intervention (SAM), or a combined intervention (FAST+SAM) on physical activity (ie, steps/day). We hypothesized the combined intervention would yield the greatest increase in steps/day.

methodsThis assessor-blinded multisite randomized controlled trial was conducted at 4 university/hospital-based laboratories. Participants were 21 to 85 years old, walking without physical assistance following a single, unilateral noncerebellar stroke of ≥6 months duration, and randomly assigned to FAST, SAM, or FAST+SAM for 12 weeks (2-3 sessions/week). FAST training consisted of walking-related activities at 70% to 80% heart rate reserve, while SAM received daily feedback and goal setting of walking activity (steps/day). Assessors and study statistician were masked to group assignment. The a priori-determined primary outcome and end point was a comparison of the change in steps/day between the 3 intervention groups from pre- to post-intervention. Adverse events were tracked after randomization. All randomized participants were included in the intent-to-treat analysis.

resultsParticipants were enrolled from July 18, 2016, to November 16, 2021. Of 2385 participants initially screened, 250 participants were randomized (mean [SE] age, 63 [0.80] years; 116 females/134 males), with 89 assigned to FAST, 81 to SAM, and 80 to FAST+SAM. Steps/day significantly increased in both the SAM (mean [SE], 1542 [267; 95% CI, 1014-2069]

conclusionsOnly individuals with chronic stroke who completed a step activity monitoring behavioral intervention with skilled coaching and goal progression demonstrated improvements in physical activity (steps/day). REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02835313.

Indexed as

StrokeStroke RehabilitationAdultAgedAged, 80 and overExerciseExercise TherapyFemaleHumansMaleMiddle AgedWalkingYoung Adultexercisegoalsheart ratestrokewalking

Identifiers

PMID38134254
PMCPMC10752299
OpenAlexW4390098811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.